eprintid: 1558550 rev_number: 53 eprint_status: archive userid: 608 dir: disk0/01/55/85/50 datestamp: 2017-06-03 22:21:36 lastmod: 2021-12-19 00:02:25 status_changed: 2017-08-08 14:56:54 type: article metadata_visibility: show creators_name: Yeung, J creators_name: Sivarajan, S creators_name: Treibel, TA creators_name: Rosmini, S creators_name: Fontana, M creators_name: Gillmore, JD creators_name: Hawkins, PN creators_name: Punwani, S creators_name: Moon, JC creators_name: Taylor, SA creators_name: Bandula, S title: Measurement of liver and spleen interstitial volume in patients with systemic amyloid light-chain amyloidosis using equilibrium contrast CT ispublished: pub subjects: UCH divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: FI6 divisions: G90 divisions: D14 divisions: GA4 keywords: Amyloidosis, Computer assisted, Contrast media, Extracellular space, Radiographic image interpretation, Tomography, X-ray computed note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: OBJECTIVES: To investigate equilibrium contrast-enhanced CT (EQ-CT) measurement of extracellular volume fraction (ECV) in patients with systemic amyloid light-chain (AL) amyloidosis, testing the hypothesis that ECV becomes elevated in the liver and spleen and ECV correlates with other estimates of organ amyloid burden. METHODS: 26 patients with AL amyloidosis underwent EQ-CT, and ECV was measured in the liver and spleen. Patients also underwent serum amyloid P (SAP) component scintigraphy with grading of liver and spleen involvement. Mann-Whitney U test was used to test for a difference between patients with amyloid deposition (SAP grade 1-3) and those without (SAP grade 0). Variation in ECV across SAP grades was assessed using the Kruskal-Wallis test and association between ECV and SAP grades with Spearman correlation. RESULTS: Mean ECV in the spleen and liver was significantly greater (p < 0.0005) in amyloidotic organs (SAP grade 1-3) [spleen, liver: 0.430, 0.375] compared with healthy tissues [spleen, liver: 0.304, 0.269]. ECV increased with increasing amyloid burden, showing positive correlation with SAP grade in both the liver (r = 0.758) and spleen (r = 0.867). CONCLUSION: In patients with systemic AL amyloidosis, EQ-CT can demonstrate increased spleen and liver ECV, which is associated with amyloid disease burden. date: 2017-11 date_type: published official_url: http://doi.org/10.1007/s00261-017-1194-4 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1297115 doi: 10.1007/s00261-017-1194-4 pii: 10.1007/s00261-017-1194-4 lyricists_name: Bandula, Steve lyricists_name: Fontana, Marianna lyricists_name: Gillmore, Julian lyricists_name: Hawkins, Philip lyricists_name: Moon, James lyricists_name: Punwani, Shonit lyricists_name: Taylor, Stuart lyricists_name: Treibel, Thomas Alexander lyricists_id: SBAND86 lyricists_id: MFONT56 lyricists_id: JGILL78 lyricists_id: PNHAW77 lyricists_id: JMOON31 lyricists_id: SPUNW14 lyricists_id: STAYL70 lyricists_id: TATRE28 full_text_status: public publication: Abdominal Radiology volume: 42 number: 11 pagerange: 2646-2651 event_location: United States issn: 2366-0058 citation: Yeung, J; Sivarajan, S; Treibel, TA; Rosmini, S; Fontana, M; Gillmore, JD; Hawkins, PN; ... Bandula, S; + view all <#> Yeung, J; Sivarajan, S; Treibel, TA; Rosmini, S; Fontana, M; Gillmore, JD; Hawkins, PN; Punwani, S; Moon, JC; Taylor, SA; Bandula, S; - view fewer <#> (2017) Measurement of liver and spleen interstitial volume in patients with systemic amyloid light-chain amyloidosis using equilibrium contrast CT. Abdominal Radiology , 42 (11) pp. 2646-2651. 10.1007/s00261-017-1194-4 <https://doi.org/10.1007/s00261-017-1194-4>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1558550/1/Hawkins-P_Measurement%20of%20Liver%20and%20spleen%20-%20Abdominal%20Radiology_aam.pdf