eprintid: 1558373
rev_number: 32
eprint_status: archive
userid: 608
dir: disk0/01/55/83/73
datestamp: 2017-06-03 19:16:40
lastmod: 2021-12-05 00:45:53
status_changed: 2018-01-25 15:01:04
type: article
metadata_visibility: show
creators_name: Salaman, MR
creators_name: Isenberg, DA
title: The immunological personality of close relatives of SLE patients
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G90
keywords: NK and NKT cells, Relatives of lupus patients, immunoglobulin regulation, immunological abnormalities, lupus pathogenesis
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abstract: Immunological abnormalities seen in relatives of patients with autoimmune disorders can be useful in understanding the pathogenesis of the disease since, unlike in patients, they cannot result from the disease process or drug treatment. In this article we present a brief overview of our studies of the basic immunological status of close relatives of SLE patients. We looked at blood levels of IgG, IgM and antibodies to double-stranded DNA, as well as at NK cell numbers and cytotoxic activity and the levels of NKT, B and T cells. As many as 60% of relatives showed one or more abnormalities in these assays. Most notably there were increased levels of IgG in male and female relatives and a reduction of IgM in females. IgG correlated inversely with NKT cell numbers adding strength to the concept that the presence of IgG autoantibodies in patients is due to impaired regulation by NKT cells. IgM, on the other hand, correlated inversely with NK cells which may thus have a role in bringing about the reduced IgM seen in some patients. Immunological abnormalities were found to be more often associated with parents and offspring of patients than with their siblings, pointing to the involvement of environmental or epigenetic influences in lupus pathogenesis.
date: 2017-12-01
date_type: published
official_url: http://doi.org/10.1177/0961203317707826
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1296880
doi: 10.1177/0961203317707826
lyricists_name: Isenberg, David
lyricists_id: DAISE40
full_text_status: public
publication: Lupus
volume: 26
number: 14
pagerange: 1513-1516
event_location: England
issn: 1477-0962
citation:        Salaman, MR;    Isenberg, DA;      (2017)    The immunological personality of close relatives of SLE patients.                   Lupus , 26  (14)   pp. 1513-1516.    10.1177/0961203317707826 <https://doi.org/10.1177/0961203317707826>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1558373/1/Isenberg_0961203317707826.pdf