eprintid: 1558303
rev_number: 25
eprint_status: archive
userid: 608
dir: disk0/01/55/83/03
datestamp: 2017-06-05 13:29:16
lastmod: 2021-09-20 22:26:10
status_changed: 2017-06-05 13:29:16
type: article
metadata_visibility: show
creators_name: Li, H
creators_name: Williams, GR
creators_name: Wu, J
creators_name: Wang, H
creators_name: Sun, X
creators_name: Zhu, L-M
title: Poly(N-isopropylacrylamide)/poly(l-lactic acid-co-ɛ-caprolactone) fibers loaded with ciprofloxacin as wound dressing materials
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: Wound dressing; Electrospinning; Thermosensitive; PNIPAAm; Antibacterial
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: In this work, we aimed to develop new materials to reduce the secondary injuries which can be imparted when replacing wound dressings. Electrospun fibers based on the thermoresponsive polymer poly(N-isopropylacrylamide) (PNIPAAm), poly(l-lactic acid-co-ɛ-caprolactone) (PLCL), and the antibiotic ciprofloxacin (CIF) were prepared. The water contact angle of fibers made from a blend of PNIPAAm and PLCL changed dramatically when the temperature was increased above 32 °C. Sustained release of CIF from the formulations was observed over > 200 h. Moreover, L929 fibroblasts could proliferate on the fibers, indicating their biocompatibility. The CIF-loaded fibers were found to have potent antibacterial activity against E. coli and S. aureus. In vivo tests on rats indicated that CIF-loaded thermosensitive fibers have enhanced healing performance compared to CIF-loaded PLCL fibers or a commercial gauze. Electrospun PNIPAAm/PLCL fibers loaded with CIF thus have great promise in the development of new wound dressing materials.
date: 2017-10
date_type: published
official_url: http://dx.doi.org/10.1016/j.msec.2017.04.058
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1296947
doi: 10.1016/j.msec.2017.04.058
lyricists_name: Williams, Gareth
lyricists_id: GWILL02
actors_name: Williams, Gareth
actors_id: GWILL02
actors_role: owner
full_text_status: public
publication: Materials Science and Engineering: C
volume: 79
pagerange: 245-254
issn: 0928-4931
citation:        Li, H;    Williams, GR;    Wu, J;    Wang, H;    Sun, X;    Zhu, L-M;      (2017)    Poly(N-isopropylacrylamide)/poly(l-lactic acid-co-ɛ-caprolactone) fibers loaded with ciprofloxacin as wound dressing materials.                   Materials Science and Engineering: C , 79    pp. 245-254.    10.1016/j.msec.2017.04.058 <https://doi.org/10.1016/j.msec.2017.04.058>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1558303/1/Heyu%20MSE-C%20accepted%20version.pdf