@article{discovery1558303,
         journal = {Materials Science and Engineering: C},
           pages = {245--254},
           title = {Poly(N-isopropylacrylamide)/poly(l-lactic acid-co-?-caprolactone) fibers loaded with ciprofloxacin as wound dressing materials},
            year = {2017},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
          volume = {79},
           month = {October},
        keywords = {Wound dressing; Electrospinning; Thermosensitive; PNIPAAm; Antibacterial},
          author = {Li, H and Williams, GR and Wu, J and Wang, H and Sun, X and Zhu, L-M},
            issn = {0928-4931},
        abstract = {In this work, we aimed to develop new materials to reduce the secondary injuries which can be imparted when replacing wound dressings. Electrospun fibers based on the thermoresponsive polymer poly(N-isopropylacrylamide) (PNIPAAm), poly(l-lactic acid-co-?-caprolactone) (PLCL), and the antibiotic ciprofloxacin (CIF) were prepared. The water contact angle of fibers made from a blend of PNIPAAm and PLCL changed dramatically when the temperature was increased above 32 oC. Sustained release of CIF from the formulations was observed over {\ensuremath{>}} 200 h. Moreover, L929 fibroblasts could proliferate on the fibers, indicating their biocompatibility. The CIF-loaded fibers were found to have potent antibacterial activity against E. coli and S. aureus. In vivo tests on rats indicated that CIF-loaded thermosensitive fibers have enhanced healing performance compared to CIF-loaded PLCL fibers or a commercial gauze. Electrospun PNIPAAm/PLCL fibers loaded with CIF thus have great promise in the development of new wound dressing materials.},
             url = {http://dx.doi.org/10.1016/j.msec.2017.04.058}
}