<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/title> "Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/abstract> "Background International consensus recognises four medulloblastoma molecular subgroups: WNT (MBWNT), SHH\r\n(MBSHH), group 3 (MBGrp3), and group 4 (MBGrp4), each defined by their characteristic genome-wide transcriptomic and\r\nDNA methylomic profiles. These subgroups have distinct clinicopathological and molecular features, and underpin\r\ncurrent disease subclassification and initial subgroup-directed therapies that are underway in clinical trials. However,\r\nsubstantial biological heterogeneity and differences in survival are apparent within each subgroup, which remain to\r\nbe resolved. We aimed to investigate whether additional molecular subgroups exist within childhood medulloblastoma\r\nand whether these could be used to improve disease subclassification and prognosis predictions.\r\nMethods In this retrospective cohort study, we assessed 428 primary medulloblastoma samples collected from UK\r\nChildren’s Cancer and Leukaemia Group (CCLG) treatment centres (UK), collaborating European institutions, and\r\nthe UKCCSG-SIOP-PNET3 European clinical trial. An independent validation cohort (n=276) of archival tumour\r\nsamples was also analysed. We analysed samples from patients with childhood medulloblastoma who were aged\r\n0–16 years at diagnosis, and had central review of pathology and comprehensive clinical data. We did comprehensive\r\nmolecular profiling, including DNA methylation microarray analysis, and did unsupervised class discovery of test and\r\nvalidation cohorts to identify consensus primary molecular subgroups and characterise their clinical and biological\r\nsignificance. We modelled survival of patients aged 3–16 years in patients (n=215) who had craniospinal irradiation\r\nand had been treated with a curative intent.\r\nFindings Seven robust and reproducible primary molecular subgroups of childhood medulloblastoma were identified.\r\nMBWNT remained unchanged and each remaining consensus subgroup was split in two. MBSHH was split into agedependent\r\nsubgroups corresponding to infant (<4·3 years; MBSHH-Infant; n=65) and childhood patients (≥4·3 years;\r\nMBSHH-Child; n=38). MBGrp3 and MBGrp4 were each split into high-risk (MBGrp3-HR [n=65] and MBGrp4-HR [n=85]) and low-risk\r\n(MBGrp3-LR [n=50] and MBGrp4-LR [n=73]) subgroups. These biological subgroups were validated in the independent cohort.\r\nWe identified features of the seven subgroups that were predictive of outcome. Cross-validated subgroup-dependent\r\nsurvival models, incorporating these novel subgroups along with secondary clinicopathological and molecular features\r\nand established disease risk-factors, outperformed existing disease risk-stratification schemes. These subgroupdependent\r\nmodels stratified patients into four clinical risk groups for 5-year progression-free survival: favourable risk\r\n(54 [25%] of 215 patients; 91% survival [95% CI 82–100]); standard risk (50 [23%] patients; 81% survival [70–94]); highrisk\r\n(82 [38%] patients; 42% survival [31–56]); and very high-risk (29 [13%] patients; 28% survival [14–56]).\r\nInterpretation The discovery of seven novel, clinically significant subgroups improves disease risk-stratification and\r\ncould inform treatment decisions. These data provide a new foundation for future research and clinical investigations."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/date> "2017-05-22" .
<https://discovery.ucl.ac.uk/id/document/429446> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/volume> "18" .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/issue> "7" .
<https://discovery.ucl.ac.uk/id/org/ext-9ab12bce4ed1db8d63802ba79cf39587> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-9ab12bce4ed1db8d63802ba79cf39587> <http://xmlns.com/foaf/0.1/name> "ELSEVIER SCIENCE INC"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/publication/ext-14745488> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-14745488> <http://xmlns.com/foaf/0.1/name> "Lancet Oncology"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/publication/ext-14745488> <http://purl.org/ontology/bibo/issn> "14745488" .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
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<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-a520096536be8edbe6bb3a76d201b0d0> .
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<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-67016a157503791be762af9443591926> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-888741e6d47ceac5a55c2acd79967147> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-888741e6d47ceac5a55c2acd79967147> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fb444fe97826691394af282355d8b953> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-fb444fe97826691394af282355d8b953> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-327c93f4b237404f6a5cd1254105cb90> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-327c93f4b237404f6a5cd1254105cb90> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-397bece96bb9327b0eb3c3cef7c18b44> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-397bece96bb9327b0eb3c3cef7c18b44> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dfbad1677eaeac2c3b50af6fee120943> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-dfbad1677eaeac2c3b50af6fee120943> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cfcda637d0920cc04946ab6aa18d7a43> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-cfcda637d0920cc04946ab6aa18d7a43> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a9fa8e620bc2f2e8ba573ef37e7f24ed> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-a9fa8e620bc2f2e8ba573ef37e7f24ed> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e70d37013313310c2fef6be246601a53> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-e70d37013313310c2fef6be246601a53> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4d09423757521d40f2dac1a66a5e91de> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-4d09423757521d40f2dac1a66a5e91de> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e2aea37c2a2391062078a77b5af1d25b> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-e2aea37c2a2391062078a77b5af1d25b> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-36f5f38a7f884ad6a7f0b259db884a05> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-36f5f38a7f884ad6a7f0b259db884a05> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e61bbd0427f2e843e4283586f5ca1667> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-e61bbd0427f2e843e4283586f5ca1667> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3b1ed56558a292d6d64f295dbc9d3d32> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-3b1ed56558a292d6d64f295dbc9d3d32> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-58b25c4853245672cb660219f35ba7d2> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-58b25c4853245672cb660219f35ba7d2> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-00669fc38ded6d93ab651cf56ad9c7bf> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1558227#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-00669fc38ded6d93ab651cf56ad9c7bf> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-479a3af3c53d1b73c5197a9fc5167bb4> .
<https://discovery.ucl.ac.uk/id/eprint/1558227> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1558227#authors> .
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<https://discovery.ucl.ac.uk/id/person/ext-479a3af3c53d1b73c5197a9fc5167bb4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-479a3af3c53d1b73c5197a9fc5167bb4> <http://xmlns.com/foaf/0.1/givenName> "SC"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-479a3af3c53d1b73c5197a9fc5167bb4> <http://xmlns.com/foaf/0.1/familyName> "Clifford"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-479a3af3c53d1b73c5197a9fc5167bb4> <http://xmlns.com/foaf/0.1/name> "SC Clifford"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-67016a157503791be762af9443591926> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-67016a157503791be762af9443591926> <http://xmlns.com/foaf/0.1/givenName> "JC"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-67016a157503791be762af9443591926> <http://xmlns.com/foaf/0.1/familyName> "Lindsey"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-67016a157503791be762af9443591926> <http://xmlns.com/foaf/0.1/name> "JC Lindsey"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-327c93f4b237404f6a5cd1254105cb90> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-327c93f4b237404f6a5cd1254105cb90> <http://xmlns.com/foaf/0.1/givenName> "AJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-327c93f4b237404f6a5cd1254105cb90> <http://xmlns.com/foaf/0.1/familyName> "Smith"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-327c93f4b237404f6a5cd1254105cb90> <http://xmlns.com/foaf/0.1/name> "AJ Smith"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e61bbd0427f2e843e4283586f5ca1667> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e61bbd0427f2e843e4283586f5ca1667> <http://xmlns.com/foaf/0.1/givenName> "SB"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e61bbd0427f2e843e4283586f5ca1667> <http://xmlns.com/foaf/0.1/familyName> "Wharton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e61bbd0427f2e843e4283586f5ca1667> <http://xmlns.com/foaf/0.1/name> "SB Wharton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-00669fc38ded6d93ab651cf56ad9c7bf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-00669fc38ded6d93ab651cf56ad9c7bf> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-00669fc38ded6d93ab651cf56ad9c7bf> <http://xmlns.com/foaf/0.1/familyName> "Williamson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-00669fc38ded6d93ab651cf56ad9c7bf> <http://xmlns.com/foaf/0.1/name> "D Williamson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-397bece96bb9327b0eb3c3cef7c18b44> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-397bece96bb9327b0eb3c3cef7c18b44> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-397bece96bb9327b0eb3c3cef7c18b44> <http://xmlns.com/foaf/0.1/familyName> "Hicks"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-397bece96bb9327b0eb3c3cef7c18b44> <http://xmlns.com/foaf/0.1/name> "D Hicks"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fb444fe97826691394af282355d8b953> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fb444fe97826691394af282355d8b953> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fb444fe97826691394af282355d8b953> <http://xmlns.com/foaf/0.1/familyName> "Crosier"^^<http://www.w3.org/2001/XMLSchema#string> .
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