eprintid: 1557936
rev_number: 43
eprint_status: archive
userid: 608
dir: disk0/01/55/79/36
datestamp: 2017-10-16 15:00:23
lastmod: 2021-09-25 23:05:26
status_changed: 2017-10-20 15:46:24
type: article
metadata_visibility: show
creators_name: Mallandrich, M
creators_name: Fernández-Campos, F
creators_name: Clares, B
creators_name: Halbaut, L
creators_name: Alonso, C
creators_name: Coderch, L
creators_name: Garduño-Ramirez, ML
creators_name: Andrade, B
creators_name: Del Pozo, A
creators_name: Lane, ME
creators_name: Calpena, AC
title: Developing Transdermal Applications of Ketorolac Tromethamine Entrapped in Stimuli Sensitive Block Copolymer Hydrogels
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: carbomer, hydrogels, ketorolac, tromethamine, poloxamer, transdermal
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Purpose: In order to obtain dermal vehicles of ketorolac tromethamine (KT) for the local treatment of inflammation and restrict undesirable side effects of systemic levels hydrogels (HGs) of poloxamer and carbomer were developed. / Methods: KT poloxamer based HG (KT-P407-HG) and KT carbomer based HG (KT-C940-HG) were elaborated and characterized in terms of swelling, degradation, porosity, rheology, stability, in vitro release, ex vivo permeation and distribution skin layers. Finally, in vivo anti-inflammatory efficacy and skin tolerance were also assessed. / Results: HGs were transparent and kept stable after 3 months exhibiting biocompatible near neutral pH values. Rheological patterns fitted to Herschel-Bulkley for KT-C940-HG and Newton for KT-P407-HG due to its low viscosity at 25°C. Rapid release profiles were observed through first order kinetics. Following the surface the highest concentration of KT from C940-HG was found in the epidermis and the stratum corneum for P407-HG. Relevant anti-inflammatory efficacy of KT-P407-HG revealed enough ability to provide sufficient bioavailability KT to reach easily the site of action. The application of developed formulations in volunteers did not induce any visual skin irritation. / Conclusions: KT-P407-HG was proposed as suitable formulation for anti-inflammatory local treatment without theoretical systemic side effect.
date: 2017-08
date_type: published
publisher: SPRINGER/PLENUM PUBLISHERS
official_url: http://dx.doi.org/10.1007/s11095-017-2181-8
oa_status: green
full_text_type: other
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1296721
doi: 10.1007/s11095-017-2181-8
lyricists_name: Lane, Majella
lyricists_id: MLANE69
actors_name: Allington-Smith, Dominic
actors_id: DAALL44
actors_role: owner
full_text_status: public
publication: Pharmaceutical Research
volume: 34
number: 8
pagerange: 1728-1740
pages: 13
issn: 1573-904X
citation:        Mallandrich, M;    Fernández-Campos, F;    Clares, B;    Halbaut, L;    Alonso, C;    Coderch, L;    Garduño-Ramirez, ML;                 ... Calpena, AC; + view all <#>        Mallandrich, M;  Fernández-Campos, F;  Clares, B;  Halbaut, L;  Alonso, C;  Coderch, L;  Garduño-Ramirez, ML;  Andrade, B;  Del Pozo, A;  Lane, ME;  Calpena, AC;   - view fewer <#>    (2017)    Developing Transdermal Applications of Ketorolac Tromethamine Entrapped in Stimuli Sensitive Block Copolymer Hydrogels.                   Pharmaceutical Research , 34  (8)   pp. 1728-1740.    10.1007/s11095-017-2181-8 <https://doi.org/10.1007/s11095-017-2181-8>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1557936/1/Lane_Mallandrich.pdf