TY  - JOUR
JF  - Neuroscience
A1  - Varlet, M
A1  - Wade, A
A1  - Novembre, G
A1  - Keller, PE
UR  - http://doi.org/10.1016/j.neuroscience.2017.03.016
SN  - 1873-7544
N1  - © 2017 IBRO. Published by Elsevier Ltd. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
SP  - 75
VL  - 350
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Neurosciences
KW  -  Neurosciences & Neurology
KW  -  tACS
KW  -  entrainment
KW  -  self-paced rhythmic movement
KW  -  frequency-dependent side effects
KW  -  PRIMARY MOTOR CORTEX
KW  -  PARKINSONS-DISEASE
KW  -  CORTICOKINEMATIC COHERENCE
KW  -  INTERPERSONAL COORDINATION
KW  -  CORTICAL EXCITABILITY
KW  -  HAND MOVEMENTS
KW  -  ENTRAINMENT
KW  -  SYNCHRONIZATION
KW  -  OSCILLATIONS
KW  -  FREQUENCY
N2  - Human rhythmic movements spontaneously entrain to external rhythmic stimuli. Such sensory-motor entrainment can attract movements to different tempi and enhance their efficiency, with potential clinical applications for motor rehabilitation. Here we investigate whether entrainment of self-paced rhythmic movements can be induced via transcranial alternating current stimulation (tACS), which uses alternating currents to entrain spontaneous brain oscillations at specific frequencies. Participants swung a handheld pendulum at their preferred tempo with the right hand while tACS was applied over their left or right primary motor cortex at frequencies equal to their preferred tempo (Experiment 1) or in the alpha (10 Hz) and beta (20 Hz) ranges (Experiment 2). Given that entrainment generally occurs only if the frequency difference between two rhythms is small, stimulations were delivered at frequencies equal to participants? preferred movement tempo (?1 Hz) and ±12.5% in Experiment 1, and at 10 Hz and 20 Hz, and ±12.5% in Experiment 2. The comparison of participants? movement frequency, amplitude, variability, and phase synchrony with and without tACS failed to reveal entrainment or movement modifications across the two experiments. However, significant differences in stimulation-related side effects reported by participants were found between the two experiments, with phosphenes and burning sensations principally occurring in Experiment 2, and metallic tastes reported marginally more often in Experiment 1. Although other stimulation protocols may be effective, our results suggest that rhythmic movements such as pendulum swinging or locomotion that are low in goal-directedness and/or strongly driven by peripheral and mechanical constraints may not be susceptible to modulation by tACS.
ID  - discovery1556049
PB  - PERGAMON-ELSEVIER SCIENCE LTD
TI  - Investigation of the effects of transcranial alternating current stimulation (tACS) on self-paced rhythmic movements
Y1  - 2017/05/14/
AV  - public
EP  - 84
ER  -