eprintid: 1554652
rev_number: 24
eprint_status: archive
userid: 608
dir: disk0/01/55/46/52
datestamp: 2017-09-29 12:15:45
lastmod: 2020-06-01 06:10:09
status_changed: 2017-09-29 12:15:45
type: thesis
metadata_visibility: show
creators_name: Topcu, AA
title: Microfluidic-assisted encapsulation in biocompatible multi-polymeric particles
ispublished: unpub
divisions: UCL
divisions: A01
divisions: B04
divisions: C05
keywords: Microfluidic, microfluidic encapsulation, drug delivery, controlled drug release, colloidal emulsion, quasicrystals
abstract: Microfluidic-assisted fabrication of bidegradable, multicompartment polymeric carriers is investigated in this study by utilizing a facile self-assembly route. The structure for this PhD research involves two main sections. In the first part, microfluidic self-assembly route was used to generate polymeric quasicrystalline ternary arrays confirming the universality of quasicrystals. A novel K-junction microfluidic device (KJM) was utilized to generate N2-cored bubbles with colloidal emulsion on the shell that induce self-assembly of polymeric particle patterns upon bubble bursting and solvent evaporation. The polymeric quasicrystals comprising three biocompatible polymers generated in this way produced uniform particles consisting of hydrophilic/hydrophobic segments and were tagged with fluorescent dyes to confirm their multipolymeric structure. They display a radially decreasing particle size; the mechanism of self-assembly is explained by heterogeneous nucleation that culminates in heptagonal quasiperiodic polymer pattern formation. The ordered, non-periodic Archimedean tiling of the particles exhibited rare 7-fold symmetry and provide a generation route for stable soft matter quasicrystals. The second part focuses on model drug encapsulation in polymeric carriers. Monodisperse microbubbles were generated that release biodegradable polymeric nanoparticles (NP) from a thin bubble film during evaporation. PEG/PLGA NPs provide an excellent platform for delivery of multiple poorly water soluble drugs and were utilized for non-covalent encapsulation of an immiscible model drug combination of paracetamol (PAR) / ibuprofen (IBU). The particle generation mechanism indicates that colloidal emulsion on microbubble film produces NPs via nanoprecipitation ranging between 220 ± 48 nm and 393 ± 66 nm. PEG/PLGA nanoparticles encapsulating a dual combination of hydrophobic drugs (PAR/IBU) were prepared reproducibly via microfluidic mixing, with control over size, distribution and their subsequent release was shown to be extended. In vitro drug release studies demonstrate extended release, which can be tuned further by controlling experiment parameters, thereby offering potential utilization of versatile microfluidic-assisted method to develop potential combined therapies with controlled drug release behaviour.
date: 2017-05-28
date_type: published
oa_status: green
full_text_type: other
thesis_class: doctoral_open
language: eng
thesis_view: UCL_Thesis
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1291707
lyricists_name: Topcu, Ahmet
lyricists_id: AATOP02
actors_name: Topcu, Ahmet
actors_id: AATOP02
actors_role: owner
full_text_status: public
pages: 204
event_title: University College London
institution: UCL (University College London)
department: Mechanical engineering
thesis_type: Doctoral
editors_name: Edirisinghe, M
editors_name: Orlu Gul, M
citation:        Topcu, AA;      (2017)    Microfluidic-assisted encapsulation in biocompatible multi-polymeric particles.                   Doctoral thesis , UCL (University College London).     Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1554652/1/Atopcu%20PhD%20Thesis%20final.pdf