eprintid: 1552440 rev_number: 36 eprint_status: archive userid: 608 dir: disk0/01/55/24/40 datestamp: 2017-04-22 20:13:29 lastmod: 2021-12-13 02:51:34 status_changed: 2017-06-05 15:20:54 type: article metadata_visibility: show creators_name: Dixon, SC creators_name: Nagle, CM creators_name: Wentzensen, N creators_name: Trabert, B creators_name: Beeghly-Fadiel, A creators_name: Schildkraut, JM creators_name: Moysich, KB creators_name: deFazio, A creators_name: Risch, HA creators_name: Rossing, MA creators_name: Doherty, JA creators_name: Wicklund, KG creators_name: Goodman, MT creators_name: Modugno, F creators_name: Ness, RB creators_name: Edwards, RP creators_name: Jensen, A creators_name: Kjaer, SK creators_name: Hogdall, E creators_name: Berchuck, A creators_name: Cramer, DW creators_name: Terry, KL creators_name: Poole, EM creators_name: Bandera, EV creators_name: Paddock, LE creators_name: Anton-Culver, H creators_name: Ziogas, A creators_name: Menon, U creators_name: Gayther, SA creators_name: Ramus, SJ creators_name: Gentry-Maharaj, A creators_name: Pearce, CL creators_name: Wu, AH creators_name: Pike, MC creators_name: Webb, PM title: Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium ispublished: pub divisions: UCL divisions: B02 divisions: D65 divisions: J38 keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Ovarian Cancer, Aspirin, Nonsteroidal Anti-Inflammatory Drugs, NSAID, Paracetamol, Acetaminophen, Pooled Analysis, Survival, Nonsteroidal Antiinflammatory Drugs, Aspirin, Metaanalysis, Diagnosis note: © 2017 Cancer Research UK. All rights reserved abstract: BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. Methods: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths). RESULTS: Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88–1.04); non-aspirin NSAIDs 0.97 (0.89–1.05); acetaminophen 1.01 (0.93–1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR ¼ 0.89 (0.82–0.98)). CONCLUSIONS: Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted. date: 2017-04-25 date_type: published publisher: NATURE PUBLISHING GROUP official_url: http://dx.doi.org/10.1038/bjc.2017.68 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Article verified: verified_manual elements_id: 1284721 doi: 10.1038/bjc.2017.68 language_elements: eng lyricists_name: Gentry-Maharaj, Aleksandra lyricists_name: Menon, Usha lyricists_id: AGENT07 lyricists_id: UMENO29 full_text_status: public publication: British Journal of Cancer volume: 116 number: 9 pagerange: 1223-1228 pages: 6 issn: 1532-1827 citation: Dixon, SC; Nagle, CM; Wentzensen, N; Trabert, B; Beeghly-Fadiel, A; Schildkraut, JM; Moysich, KB; ... Webb, PM; + view all <#> Dixon, SC; Nagle, CM; Wentzensen, N; Trabert, B; Beeghly-Fadiel, A; Schildkraut, JM; Moysich, KB; deFazio, A; Risch, HA; Rossing, MA; Doherty, JA; Wicklund, KG; Goodman, MT; Modugno, F; Ness, RB; Edwards, RP; Jensen, A; Kjaer, SK; Hogdall, E; Berchuck, A; Cramer, DW; Terry, KL; Poole, EM; Bandera, EV; Paddock, LE; Anton-Culver, H; Ziogas, A; Menon, U; Gayther, SA; Ramus, SJ; Gentry-Maharaj, A; Pearce, CL; Wu, AH; Pike, MC; Webb, PM; - view fewer <#> (2017) Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium. British Journal of Cancer , 116 (9) pp. 1223-1228. 10.1038/bjc.2017.68 <https://doi.org/10.1038/bjc.2017.68>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1552440/1/Menon_bjc201768a.pdf