eprintid: 1552440
rev_number: 36
eprint_status: archive
userid: 608
dir: disk0/01/55/24/40
datestamp: 2017-04-22 20:13:29
lastmod: 2021-12-13 02:51:34
status_changed: 2017-06-05 15:20:54
type: article
metadata_visibility: show
creators_name: Dixon, SC
creators_name: Nagle, CM
creators_name: Wentzensen, N
creators_name: Trabert, B
creators_name: Beeghly-Fadiel, A
creators_name: Schildkraut, JM
creators_name: Moysich, KB
creators_name: deFazio, A
creators_name: Risch, HA
creators_name: Rossing, MA
creators_name: Doherty, JA
creators_name: Wicklund, KG
creators_name: Goodman, MT
creators_name: Modugno, F
creators_name: Ness, RB
creators_name: Edwards, RP
creators_name: Jensen, A
creators_name: Kjaer, SK
creators_name: Hogdall, E
creators_name: Berchuck, A
creators_name: Cramer, DW
creators_name: Terry, KL
creators_name: Poole, EM
creators_name: Bandera, EV
creators_name: Paddock, LE
creators_name: Anton-Culver, H
creators_name: Ziogas, A
creators_name: Menon, U
creators_name: Gayther, SA
creators_name: Ramus, SJ
creators_name: Gentry-Maharaj, A
creators_name: Pearce, CL
creators_name: Wu, AH
creators_name: Pike, MC
creators_name: Webb, PM
title: Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium
ispublished: pub
divisions: UCL
divisions: B02
divisions: D65
divisions: J38
keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Ovarian Cancer, Aspirin, Nonsteroidal Anti-Inflammatory Drugs, NSAID, Paracetamol, Acetaminophen, Pooled Analysis, Survival, Nonsteroidal Antiinflammatory Drugs, Aspirin, Metaanalysis, Diagnosis
note: © 2017 Cancer Research UK. All rights reserved
abstract: BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited.
Methods: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among
7694 women with invasive epithelial ovarian cancer (4273 deaths).



RESULTS: Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95%
confidence intervals): aspirin 0.96 (0.88–1.04); non-aspirin NSAIDs 0.97 (0.89–1.05); acetaminophen 1.01 (0.93–1.10)), nor with
progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly
defining non-use as less than once per week (pHR ¼ 0.89 (0.82–0.98)).


CONCLUSIONS: Although this study did not show a clear association between analgesic use and ovarian cancer survival, further
investigation with clearer definitions of use and information about post-diagnosis use is warranted.
date: 2017-04-25
date_type: published
publisher: NATURE PUBLISHING GROUP
official_url: http://dx.doi.org/10.1038/bjc.2017.68
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1284721
doi: 10.1038/bjc.2017.68
language_elements: eng
lyricists_name: Gentry-Maharaj, Aleksandra
lyricists_name: Menon, Usha
lyricists_id: AGENT07
lyricists_id: UMENO29
full_text_status: public
publication: British Journal of Cancer
volume: 116
number: 9
pagerange: 1223-1228
pages: 6
issn: 1532-1827
citation:        Dixon, SC;    Nagle, CM;    Wentzensen, N;    Trabert, B;    Beeghly-Fadiel, A;    Schildkraut, JM;    Moysich, KB;                                                                                                                 ... Webb, PM; + view all <#>        Dixon, SC;  Nagle, CM;  Wentzensen, N;  Trabert, B;  Beeghly-Fadiel, A;  Schildkraut, JM;  Moysich, KB;  deFazio, A;  Risch, HA;  Rossing, MA;  Doherty, JA;  Wicklund, KG;  Goodman, MT;  Modugno, F;  Ness, RB;  Edwards, RP;  Jensen, A;  Kjaer, SK;  Hogdall, E;  Berchuck, A;  Cramer, DW;  Terry, KL;  Poole, EM;  Bandera, EV;  Paddock, LE;  Anton-Culver, H;  Ziogas, A;  Menon, U;  Gayther, SA;  Ramus, SJ;  Gentry-Maharaj, A;  Pearce, CL;  Wu, AH;  Pike, MC;  Webb, PM;   - view fewer <#>    (2017)    Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.                   British Journal of Cancer , 116  (9)   pp. 1223-1228.    10.1038/bjc.2017.68 <https://doi.org/10.1038/bjc.2017.68>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1552440/1/Menon_bjc201768a.pdf