%0 Journal Article %@ 1532-1827 %A Dixon, SC %A Nagle, CM %A Wentzensen, N %A Trabert, B %A Beeghly-Fadiel, A %A Schildkraut, JM %A Moysich, KB %A deFazio, A %A Risch, HA %A Rossing, MA %A Doherty, JA %A Wicklund, KG %A Goodman, MT %A Modugno, F %A Ness, RB %A Edwards, RP %A Jensen, A %A Kjaer, SK %A Hogdall, E %A Berchuck, A %A Cramer, DW %A Terry, KL %A Poole, EM %A Bandera, EV %A Paddock, LE %A Anton-Culver, H %A Ziogas, A %A Menon, U %A Gayther, SA %A Ramus, SJ %A Gentry-Maharaj, A %A Pearce, CL %A Wu, AH %A Pike, MC %A Webb, PM %D 2017 %F discovery:1552440 %I NATURE PUBLISHING GROUP %J British Journal of Cancer %K Science & Technology, Life Sciences & Biomedicine, Oncology, Ovarian Cancer, Aspirin, Nonsteroidal Anti-Inflammatory Drugs, NSAID, Paracetamol, Acetaminophen, Pooled Analysis, Survival, Nonsteroidal Antiinflammatory Drugs, Aspirin, Metaanalysis, Diagnosis %N 9 %P 1223-1228 %T Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium %U https://discovery.ucl.ac.uk/id/eprint/1552440/ %V 116 %X BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. Methods: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths). RESULTS: Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88–1.04); non-aspirin NSAIDs 0.97 (0.89–1.05); acetaminophen 1.01 (0.93–1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR ¼ 0.89 (0.82–0.98)). CONCLUSIONS: Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted. %Z © 2017 Cancer Research UK. All rights reserved