eprintid: 1549500 rev_number: 50 eprint_status: archive userid: 608 dir: disk0/01/54/95/00 datestamp: 2017-04-09 16:29:57 lastmod: 2021-12-06 00:42:59 status_changed: 2019-10-07 09:48:24 type: article metadata_visibility: show creators_name: Hutchinson, JC creators_name: Shelmerdine, SC creators_name: Simcock, IC creators_name: Sebire, NJ creators_name: Arthurs, OJ title: Early clinical applications for imaging at microscopic detail: microfocus computed tomography (micro-CT) ispublished: pub divisions: UCL divisions: B02 divisions: D13 divisions: G26 divisions: G25 note: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Microfocus CT (micro-CT) has traditionally been used in industry and preclinical studies, although it may find new applicability in the routine clinical setting. It can provide high-resolution three-dimensional digital imaging data sets to the same level of detail as microscopic examination without the need for tissue dissection. Micro-CT is already enabling non-invasive detailed internal assessment of various tissue specimens, particularly in breast imaging and early gestational fetal autopsy, not previously possible from more conventional modalities such as MRI or CT. In this review, we discuss the technical aspects behind micro-CT image acquisition, how early work with small animal studies have informed our knowledge of human disease and the imaging performed so far on human tissue specimens. We conclude with potential future clinical applications of this novel and emerging technique. date: 2017-05-04 date_type: published official_url: http://dx.doi.org/10.1259/bjr.20170113 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1284936 doi: 10.1259/bjr.20170113 lyricists_name: Arthurs, Owen lyricists_name: Hutchinson, John lyricists_name: Sebire, Neil lyricists_name: Shelmerdine, Susan lyricists_name: Simcock, Ian lyricists_id: OARTH57 lyricists_id: JCHUT45 lyricists_id: NJSEB45 lyricists_id: SCSHE38 lyricists_id: ICSIM28 actors_name: Dewerpe, Marie actors_id: MDDEW97 actors_role: owner full_text_status: public publication: British Journal of Radiology volume: 90 number: 1075 article_number: 20170113 event_location: England issn: 1748-880X citation: Hutchinson, JC; Shelmerdine, SC; Simcock, IC; Sebire, NJ; Arthurs, OJ; (2017) Early clinical applications for imaging at microscopic detail: microfocus computed tomography (micro-CT). British Journal of Radiology , 90 (1075) , Article 20170113. 10.1259/bjr.20170113 <https://doi.org/10.1259/bjr.20170113>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1549500/1/Sebire_bjr.20170113.pdf