TY  - JOUR
A1  - Hutchinson, JC
A1  - Shelmerdine, SC
A1  - Simcock, IC
A1  - Sebire, NJ
A1  - Arthurs, OJ
JF  - British Journal of Radiology
UR  - http://dx.doi.org/10.1259/bjr.20170113
SN  - 1748-880X
N2  - Microfocus CT (micro-CT) has traditionally been used in industry and preclinical studies, although it may find new applicability in the routine clinical setting. It can provide high-resolution three-dimensional digital imaging data sets to the same level of detail as microscopic examination without the need for tissue dissection. Micro-CT is already enabling non-invasive detailed internal assessment of various tissue specimens, particularly in breast imaging and early gestational fetal autopsy, not previously possible from more conventional modalities such as MRI or CT. In this review, we discuss the technical aspects behind micro-CT image acquisition, how early work with small animal studies have informed our knowledge of human disease and the imaging performed so far on human tissue specimens. We conclude with potential future clinical applications of this novel and emerging technique.
ID  - discovery1549500
IS  - 1075
N1  - This version is the version of record. For information on re-use, please refer to the publisher?s terms and conditions.
Y1  - 2017/05/04/
AV  - public
VL  - 90
TI  - Early clinical applications for imaging at microscopic detail: microfocus computed tomography (micro-CT)
ER  -