eprintid: 1545276
rev_number: 47
eprint_status: archive
userid: 608
dir: disk0/01/54/52/76
datestamp: 2017-03-20 10:12:19
lastmod: 2021-12-05 00:17:43
status_changed: 2019-11-22 10:19:04
type: article
metadata_visibility: show
creators_name: Tabrizi, SJ
creators_name: McColgan, P
creators_name: Gregory, S
creators_name: Seunarine, K
creators_name: Durr, A
creators_name: Raymund, R
creators_name: Leavitt, B
creators_name: Scahill, R
creators_name: Clark, C
creators_name: Langbehn, D
creators_name: Rees, G
title: Structural and Functional Brain Network Correlates of Depressive Symptoms in Premanifest Huntington’s Disease
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F83
divisions: F86
divisions: C08
divisions: D13
divisions: G26
keywords: Huntington’s disease; brain network; depression; functional MRI; diffusion tractography
note: © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
abstract: Depression is common in premanifest Huntington's disease (preHD) and results in significant morbidity. We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using diffusion tractography (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) data. A sub-network associated with depression was identified in a data-driven fashion and network-based statistics was used to investigate which specific connections correlated with depression scores. A replication analysis was then performed using data from a separate study. Correlations between depressive symptoms with increased functional connectivity and decreased structural connectivity were seen for connections in the default mode network (DMN) and basal ganglia in preHD. This study reveals specific connections in the DMN and basal ganglia that are associated with depressive symptoms in preHD.
date: 2017-06-01
date_type: published
publisher: Wiley-Blackwell
official_url: http://dx.doi.org/10.1002/hbm.23527
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1214438
doi: 10.1002/hbm.23527
lyricists_name: Clark, Christopher
lyricists_name: Gregory, Sarah
lyricists_name: McColgan, Peter
lyricists_name: Papoutsi, Marina
lyricists_name: Razi, Adeel
lyricists_name: Rees, Geraint
lyricists_name: Scahill, Rachael
lyricists_name: Seunarine, Kiran
lyricists_name: Tabrizi, Sarah
lyricists_id: CACLA01
lyricists_id: SLGRE97
lyricists_id: PEMCC11
lyricists_id: MPAPO16
lyricists_id: ARAZI49
lyricists_id: GEREE91
lyricists_id: RSCAH26
lyricists_id: KKSEU35
lyricists_id: SJTAB21
actors_name: Tabrizi, Sarah
actors_id: SJTAB21
actors_role: owner
full_text_status: public
publication: Human Brain Mapping
volume: 38
number: 6
pagerange: 2819-2829
issn: 1097-0193
citation:        Tabrizi, SJ;    McColgan, P;    Gregory, S;    Seunarine, K;    Durr, A;    Raymund, R;    Leavitt, B;                 ... Rees, G; + view all <#>        Tabrizi, SJ;  McColgan, P;  Gregory, S;  Seunarine, K;  Durr, A;  Raymund, R;  Leavitt, B;  Scahill, R;  Clark, C;  Langbehn, D;  Rees, G;   - view fewer <#>    (2017)    Structural and Functional Brain Network Correlates of Depressive Symptoms in Premanifest Huntington’s Disease.                   Human Brain Mapping , 38  (6)   pp. 2819-2829.    10.1002/hbm.23527 <https://doi.org/10.1002/hbm.23527>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1545276/1/McColgan_et_al-2017-Human_Brain_Mapping.pdf