TY  - JOUR
KW  - Huntington?s disease; brain network; depression; functional MRI; diffusion tractography
N2  - Depression is common in premanifest Huntington's disease (preHD) and results in significant morbidity. We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using diffusion tractography (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) data. A sub-network associated with depression was identified in a data-driven fashion and network-based statistics was used to investigate which specific connections correlated with depression scores. A replication analysis was then performed using data from a separate study. Correlations between depressive symptoms with increased functional connectivity and decreased structural connectivity were seen for connections in the default mode network (DMN) and basal ganglia in preHD. This study reveals specific connections in the DMN and basal ganglia that are associated with depressive symptoms in preHD.
ID  - discovery1545276
PB  - Wiley-Blackwell
TI  - Structural and Functional Brain Network Correlates of Depressive Symptoms in Premanifest Huntington?s Disease
AV  - public
Y1  - 2017/06/01/
EP  - 2829
JF  - Human Brain Mapping
A1  - Tabrizi, SJ
A1  - McColgan, P
A1  - Gregory, S
A1  - Seunarine, K
A1  - Durr, A
A1  - Raymund, R
A1  - Leavitt, B
A1  - Scahill, R
A1  - Clark, C
A1  - Langbehn, D
A1  - Rees, G
UR  - http://dx.doi.org/10.1002/hbm.23527
SN  - 1097-0193
IS  - 6
N1  - © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
SP  - 2819
VL  - 38
ER  -