eprintid: 1545130
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/01/54/51/30
datestamp: 2017-03-16 12:02:39
lastmod: 2021-09-26 22:54:32
status_changed: 2017-03-16 12:02:39
type: article
metadata_visibility: show
creators_name: Herlihy, AE
creators_name: de Bruin, RA
title: The Role of the Transcriptional Response to DNA Replication Stress
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D77
keywords: Chk1, DNA replication, DNA replication stress, E2F-dependent transcription, E2F6, checkpoint response, oncogene-induced replication stress
note: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
abstract: During DNA replication many factors can result in DNA replication stress. The DNA replication stress checkpoint prevents the accumulation of replication stress-induced DNA damage and the potential ensuing genome instability. A critical role for post-translational modifications, such as phosphorylation, in the replication stress checkpoint response has been well established. However, recent work has revealed an important role for transcription in the cellular response to DNA replication stress. In this review, we will provide an overview of current knowledge of the cellular response to DNA replication stress with a specific focus on the DNA replication stress checkpoint transcriptional response and its role in the prevention of replication stress-induced DNA damage.
date: 2017-03-02
date_type: published
official_url: http://doi.org/10.3390/genes8030092
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1213043
doi: 10.3390/genes8030092
pii: genes8030092
lyricists_name: De Bruin, Robertus
lyricists_name: Herlihy, Anna
lyricists_id: RAMDE74
lyricists_id: HERLI27
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: Genes
volume: 8
number: 3
article_number: 92
event_location: Switzerland
issn: 2073-4425
citation:        Herlihy, AE;    de Bruin, RA;      (2017)    The Role of the Transcriptional Response to DNA Replication Stress.                   Genes , 8  (3)    , Article 92.  10.3390/genes8030092 <https://doi.org/10.3390/genes8030092>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1545130/1/genes-08-00092.pdf