TY  - JOUR
TI  - The Role of the Transcriptional Response to DNA Replication Stress
AV  - public
Y1  - 2017/03/02/
VL  - 8
N1  - © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
IS  - 3
ID  - discovery1545130
N2  - During DNA replication many factors can result in DNA replication stress. The DNA replication stress checkpoint prevents the accumulation of replication stress-induced DNA damage and the potential ensuing genome instability. A critical role for post-translational modifications, such as phosphorylation, in the replication stress checkpoint response has been well established. However, recent work has revealed an important role for transcription in the cellular response to DNA replication stress. In this review, we will provide an overview of current knowledge of the cellular response to DNA replication stress with a specific focus on the DNA replication stress checkpoint transcriptional response and its role in the prevention of replication stress-induced DNA damage.
SN  - 2073-4425
UR  - http://doi.org/10.3390/genes8030092
JF  - Genes
KW  - Chk1
KW  -  DNA replication
KW  -  DNA replication stress
KW  -  E2F-dependent transcription
KW  -  E2F6
KW  -  checkpoint response
KW  -  oncogene-induced replication stress
A1  - Herlihy, AE
A1  - de Bruin, RA
ER  -