eprintid: 1544974
rev_number: 25
eprint_status: archive
userid: 608
dir: disk0/01/54/49/74
datestamp: 2017-03-16 16:49:49
lastmod: 2020-05-28 19:38:45
status_changed: 2017-03-16 16:49:49
type: article
metadata_visibility: show
creators_name: Schwaiger, JP
creators_name: Loder, CD
creators_name: Dobarro, D
creators_name: Kaier, T
creators_name: Reddecliffe, S
creators_name: Schreiber, BE
creators_name: Handler, C
creators_name: Denton, CP
creators_name: Coghlan, JG
title: Optical coherence tomography evaluation of pulmonary arterial vasculopathy in Systemic Sclerosis
ispublished: pub
divisions: UCL
divisions: A01
divisions: B02
divisions: C10
divisions: D17
divisions: G90
keywords: Interventional cardiology; Systemic sclerosis; Thrombosis
note: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
abstract: Our current understanding of the pathophysiology of pulmonary vascular disease is incomplete, since information about alterations of the pulmonary vasculature in pulmonary arterial hypertension (PAH) is primarily provided by autopsy or tissue specimens. The aim of this study was to compare the distal pulmonary vasculature of <2 mm in diameter in Systemic Sclerosis (SSc) patients with (n = 17) and without (n = 5) associated PAH using Optical Coherence Tomography during Right Heart catheterization. SSc-PAH patients showed significant thickening of Intima Media Thickening Area compared to patients without PAH (27 +/- 5.8% vs. 21 +/- 1.4%, p = 0.024). A good haemodynamic response to previous targeted PAH treatment was associated with a significantly greater number of small pulmonary artery side branches <300 μm per cm vessel (3.8 +/- 1.1 vs. 1.8 +/- 1.1; p = 0.010) and not associated with Intima Media thickening Area (26 +/- 5.4% vs. 28 +/- 6.7%; p = 0.6). Unexpected evidence of pulmonary artery thrombus formation was found in 19% of SSc-PAH patients. This is the first in-vivo study demonstrating a direct link between a structural abnormality of pulmonary arteries and a response to targeted treatment in PAH. Intravascular imaging may identify subgroups that may benefit from anticoagulation.
date: 2017-02-24
date_type: published
official_url: http://dx.doi.org/10.1038/srep43304
oa_status: green
full_text_type: pub
pmcid: PMC5324107
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1212045
doi: 10.1038/srep43304
pii: srep43304
lyricists_name: Denton, Christopher
lyricists_name: Handler, Clive
lyricists_name: Schreiber, Benjamin
lyricists_id: CPDEN87
lyricists_id: CHAND36
lyricists_id: BESCH99
actors_name: Denton, Christopher
actors_id: CPDEN87
actors_role: owner
full_text_status: public
publication: Scientific Reports
volume: 7
article_number: 43304
event_location: England
issn: 2045-2322
citation:        Schwaiger, JP;    Loder, CD;    Dobarro, D;    Kaier, T;    Reddecliffe, S;    Schreiber, BE;    Handler, C;         ... Coghlan, JG; + view all <#>        Schwaiger, JP;  Loder, CD;  Dobarro, D;  Kaier, T;  Reddecliffe, S;  Schreiber, BE;  Handler, C;  Denton, CP;  Coghlan, JG;   - view fewer <#>    (2017)    Optical coherence tomography evaluation of pulmonary arterial vasculopathy in Systemic Sclerosis.                   Scientific Reports , 7     , Article 43304.  10.1038/srep43304 <https://doi.org/10.1038/srep43304>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1544974/1/reprint%20Schwaiger_et_al-2017-Scientific_Reports.pdf
document_url: https://discovery.ucl.ac.uk/id/eprint/1544974/3/Schwaiger_Optical_coherence_tomography_Suppl.pdf