eprintid: 1544919
rev_number: 40
eprint_status: archive
userid: 608
dir: disk0/01/54/49/19
datestamp: 2017-03-14 15:45:20
lastmod: 2021-12-10 23:38:48
status_changed: 2017-04-04 10:31:23
type: article
metadata_visibility: show
creators_name: Pang, C
creators_name: Ibrahim, A
creators_name: Bulstrode, NW
creators_name: Ferretti, P
title: An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G22
keywords: Biomaterials, Growth factors, Regenerative medicine, Stem cells, Tissue engineering, Wound healing
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: The global burden of disease associated with wounds is an increasingly significant public health concern. Current treatments are often expensive, time-consuming and limited in their efficacy in chronic wounds. The challenge of overcoming current barriers associated with wound care requires innovative management techniques. Regenerative medicine is an emerging field of research that focuses on the repair, replacement or regeneration of cells, tissues or organs to restore impaired function. This article provides an overview of the pathophysiology of wound healing and reviews the latest evidence on the application of the principal components of regenerative medicine (growth factors, stem cell transplantation, biomaterials and tissue engineering) as therapeutic targets. Improved knowledge and understanding of the pathophysiology of wound healing has pointed to new therapeutic targets. Regenerative medicine has the potential to underpin the design of specific target therapies in acute and chronic wound healing. This personalised approach could eventually reduce the burden of disease associated with wound healing. Further evidence is required in the form of large animal studies and clinical trials to assess long-term efficacy and safety of these new treatments.
date: 2017-06
date_type: published
official_url: http://dx.doi.org/10.1111/iwj.12735
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1213129
doi: 10.1111/iwj.12735
lyricists_name: Bulstrode, Neil
lyricists_name: Ferretti, Patrizia
lyricists_name: Ibrahim, Amel
lyricists_id: NWBUL03
lyricists_id: PFERR04
lyricists_id: AEAIB64
actors_name: Ferretti, Patrizia
actors_id: PFERR04
actors_role: owner
full_text_status: public
publication: International Wound Journal
volume: 14
number: 3
pagerange: 450-459
event_location: England
issn: 1742-481X
citation:        Pang, C;    Ibrahim, A;    Bulstrode, NW;    Ferretti, P;      (2017)    An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing.                   International Wound Journal , 14  (3)   pp. 450-459.    10.1111/iwj.12735 <https://doi.org/10.1111/iwj.12735>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1544919/1/Ibrahim_International%20wound%20journal%20An%20overview%20of%20the%20therapeutic%20potential%20of%20regenerative%20medicine%20in%20wound%20healing%20Accepted%20manuscript.pdf