eprintid: 1544234
rev_number: 30
eprint_status: archive
userid: 608
dir: disk0/01/54/42/34
datestamp: 2017-03-10 11:49:20
lastmod: 2021-09-24 22:03:26
status_changed: 2017-08-11 10:32:49
type: article
metadata_visibility: show
creators_name: Elyas, E
creators_name: Papaevangelou, E
creators_name: Alles, EJ
creators_name: Erler, JT
creators_name: Cox, TR
creators_name: Robinson, SP
creators_name: Bamber, JC
title: Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F42
keywords: Biological physics, Cancer imaging
note: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
abstract: The objective of this study was to evaluate the potential value of ultrasound (US) shear wave elastography (SWE) in assessing the relative change in elastic modulus in colorectal adenocarcinoma xenograft models in vivo and investigate any correlation with histological analysis. We sought to test whether non-invasive evaluation of tissue stiffness is indicative of pathological tumour changes and can be used to monitor therapeutic efficacy. US-SWE was performed in tumour xenografts in 15 NCr nude immunodeficient mice, which were treated with either the cytotoxic drug, Irinotecan, or saline as control. Ten tumours were imaged 48 hours post-treatment and five tumours were imaged for up to five times after treatment. All tumours were harvested for histological analysis and comparison with elasticity measurements. Elastic (Young's) modulus prior to treatment was correlated with tumour volume (r = 0.37, p = 0.008). Irinotecan administration caused significant delay in the tumour growth (p = 0.02) when compared to control, but no significant difference in elastic modulus was detected. Histological analysis revealed a significant correlation between tumour necrosis and elastic modulus (r = −0.73, p = 0.026). SWE measurement provided complimentary information to other imaging modalities and could indicate potential changes in the mechanical properties of tumours, which in turn could be related to the stages of tumour development.
date: 2017-03-13
date_type: published
publisher: Nature Publishing Group
official_url: http://dx.doi.org/10.1038/s41598-017-00144-5
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1212810
doi: 10.1038/s41598-017-00144-5
lyricists_name: Alles, Erwin
lyricists_id: EJALL00
actors_name: Alles, Erwin
actors_id: EJALL00
actors_role: owner
full_text_status: public
publication: Scientific Reports
volume: 7
article_number: 165
issn: 2045-2322
citation:        Elyas, E;    Papaevangelou, E;    Alles, EJ;    Erler, JT;    Cox, TR;    Robinson, SP;    Bamber, JC;      (2017)    Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model.                   Scientific Reports , 7     , Article 165.  10.1038/s41598-017-00144-5 <https://doi.org/10.1038/s41598-017-00144-5>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1544234/7/Correlation%20of%20Ultrasound%20Shear%20Wave%20Elastography%20with%20Pathological%20Analysis%20in%20a%20Xenografic%20Tumour%20Model.pdf