eprintid: 1542539
rev_number: 41
eprint_status: archive
userid: 608
dir: disk0/01/54/25/39
datestamp: 2017-02-28 10:20:04
lastmod: 2021-12-30 23:22:24
status_changed: 2017-10-12 10:14:46
type: article
metadata_visibility: show
creators_name: Kirkham, FJ
title: Neurocognitive outcomes for acute global acquired brain injury in children
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G26
keywords: Cardiac arrest, cognition, encephalitis, intelligence quotient, meningitis, rehabilitation, septic shock,
traumatic brain injury
note: This is a non-final version of an article published in final form in Kirkham, FJ; (2017) Neurocognitive outcomes for acute global acquired brain injury in children. Current Opinion in Neurology 10.1097/WCO.0000000000000427. (In press).
abstract: PURPOSE OF REVIEW: In children, acute global brain injury from traumatic brain injury (TBI) and nontraumatic coma has a substantial cost to the child, the family, and the society. There have historically been relatively few studies looking at long-term cognition and behavioural outcomes. RECENT FINDINGS: Long-term follow-up studies, population-based studies, and meta-analyses are now available for TBI in children as well as adults and suggest that there is a significant cognitive cost, particularly for processing speed, working memory, and intelligence quotient (IQ) in severe TBI. Poor attention is often a premorbid deficit. Children surviving a cardiac arrest typically have a reduction in IQ. The available data for meningitis suggest that IQ is within the normal range at follow-up in most but is lower than that of matched controls. For encephalitis, the main advances have been in the recognition of additional mechanisms for postinfectious causes, including autoimmune disorders and demyelination. MRI assists with diagnosis, particularly in infectious causes, and there is some evidence that it may be useful for prognosis, particularly in TBI. SUMMARY: For the essential randomized control trials of acute treatment and rehabilitation, cognitive or MRI endpoints may become feasible as otherwise the time frame for follow-up is too long for the implementation of change.
date: 2017-02-15
date_type: published
official_url: http://dx.doi.org/10.1097/WCO.0000000000000427
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1210462
doi: 10.1097/WCO.0000000000000427
lyricists_name: Kirkham, Fenella
lyricists_id: FKIRK91
actors_name: Dewerpe, Marie
actors_id: MDDEW97
actors_role: owner
full_text_status: public
publication: Current Opinion in Neurology
volume: 30
number: 2
pagerange: 148-155
event_location: England
issn: 1473-6551
citation:        Kirkham, FJ;      (2017)    Neurocognitive outcomes for acute global acquired brain injury in children.                   Current Opinion in Neurology , 30  (2)   pp. 148-155.    10.1097/WCO.0000000000000427 <https://doi.org/10.1097/WCO.0000000000000427>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1542539/6/Kirkham_Editorial%20Kirkham%20final%20100117.pdf
document_url: https://discovery.ucl.ac.uk/id/eprint/1542539/1/Kirkham_Figure%201%20new.pdf