TY  - JOUR
AV  - public
Y1  - 2017/02/15/
EP  - 155
TI  - Neurocognitive outcomes for acute global acquired brain injury in children
KW  - Cardiac arrest
KW  -  cognition
KW  -  encephalitis
KW  -  intelligence quotient
KW  -  meningitis
KW  -  rehabilitation
KW  -  septic shock
KW  - 
traumatic brain injury
N2  - PURPOSE OF REVIEW: In children, acute global brain injury from traumatic brain injury (TBI) and nontraumatic coma has a substantial cost to the child, the family, and the society. There have historically been relatively few studies looking at long-term cognition and behavioural outcomes. RECENT FINDINGS: Long-term follow-up studies, population-based studies, and meta-analyses are now available for TBI in children as well as adults and suggest that there is a significant cognitive cost, particularly for processing speed, working memory, and intelligence quotient (IQ) in severe TBI. Poor attention is often a premorbid deficit. Children surviving a cardiac arrest typically have a reduction in IQ. The available data for meningitis suggest that IQ is within the normal range at follow-up in most but is lower than that of matched controls. For encephalitis, the main advances have been in the recognition of additional mechanisms for postinfectious causes, including autoimmune disorders and demyelination. MRI assists with diagnosis, particularly in infectious causes, and there is some evidence that it may be useful for prognosis, particularly in TBI. SUMMARY: For the essential randomized control trials of acute treatment and rehabilitation, cognitive or MRI endpoints may become feasible as otherwise the time frame for follow-up is too long for the implementation of change.
ID  - discovery1542539
IS  - 2
N1  - This is a non-final version of an article published in final form in Kirkham, FJ; (2017) Neurocognitive outcomes for acute global acquired brain injury in children. Current Opinion in Neurology 10.1097/WCO.0000000000000427. (In press).
VL  - 30
SP  - 148
A1  - Kirkham, FJ
JF  - Current Opinion in Neurology
UR  - http://dx.doi.org/10.1097/WCO.0000000000000427
SN  - 1473-6551
ER  -