%0 Journal Article %@ 1528-7505 %A Corpinot, MK %A Guo, R %A Tocher, DA %A Buanz, ABM %A Gaisford, S %A Price, SL %A Bučar, DK %D 2017 %F discovery:1542264 %J Crystal Growth and Design %N 2 %P 827-833 %T Are oxygen and sulfur atoms structurally equivalent in organic crystals? %U https://discovery.ucl.ac.uk/id/eprint/1542264/ %V 17 %X New guidelines for the design of structurally equivalent molecular crystals were derived from structural analyses of new cocrystals and polymorphs of saccharin and thiosaccharin, aided by a computational study. The study shows that isostructural crystals may be obtained through an exchange of >C?O with >C?S in the molecular components of the solids, but only if the exchanged atom is not involved in hydrogen bonding. %Z © 2016 American Chemical Society. ACS AuthorChoice - This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.