eprintid: 1542221
rev_number: 31
eprint_status: archive
userid: 608
dir: disk0/01/54/22/21
datestamp: 2017-02-24 11:07:30
lastmod: 2021-09-19 23:33:13
status_changed: 2017-05-04 13:48:08
type: article
metadata_visibility: show
creators_name: Craig, DQM
creators_name: Yang, F
creators_name: Chen, D
creators_name: Guo, Z-F
creators_name: Zhang, Y-M
creators_name: Liu, Y
creators_name: Askin, S
creators_name: Zhao, M
title: The application of novel nano-thermal and imaging techniques for monitoring drug microstructure and distribution within PLGA microspheres
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: Transition temperature microscopy; Microsphere; Bovine serum albumin; Nimodipine; Poly (d,l-lactic-co-glycolic) acid; Controlled drug release
note: Copyright © 2017. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher.
abstract: Poly (d,l-lactic-co-glycolic) acid (PLGA) based microspheres have been extensively used as controlled drug release systems. However, the burst effect has been a persistent issue associated with such systems, especially for those prepared by the double emulsion technique. An effective approach to preventing the burst effect and achieving a more ideal drug release profile is to improve the drug distribution within the polymeric matrix. Therefore, it is of great importance to establish a rapid and robust tool for screening and optimizing the drug distribution during pre-formulation. Transition Temperature Microscopy (TTM), a novel nano-thermal and imaging technique, is an extension of nano-thermal analysis (nano-TA) whereby a transition temperature is detected at a localized region of a sample and then designated a color based on a particular temperature/color palette, finally resulting in a coded map based on transition temperatures detected by carrying out a series of nanoTA measurements across the surface of the sample. In this study, we investigate the feasibility of applying the aforementioned technique combined with other thermal, imaging and structural techniques for monitoring the drug microstructure and spatial distribution within bovine serum albumin (BSA) loaded and nimodipine loaded PLGA microspheres, with a view to better predicting the in vitro drug release performance.
date: 2017-02-21
date_type: published
publisher: Elsevier
official_url: http://dx.doi.org/10.1016/j.ijpharm.2017.02.056
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1209726
doi: 10.1016/j.ijpharm.2017.02.056
lyricists_name: Askin, Sean
lyricists_name: Craig, Duncan
lyricists_id: SLASK25
lyricists_id: DQMCR05
actors_name: Craig, Duncan
actors_name: Robertson, Victoria
actors_id: DQMCR05
actors_id: VROBE74
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: International Journal of Pharmaceutics
volume: 522
number: 1-2
pagerange: 34-49
issn: 1873-3476
citation:        Craig, DQM;    Yang, F;    Chen, D;    Guo, Z-F;    Zhang, Y-M;    Liu, Y;    Askin, S;           Craig, DQM;  Yang, F;  Chen, D;  Guo, Z-F;  Zhang, Y-M;  Liu, Y;  Askin, S;  Zhao, M;   - view fewer <#>    (2017)    The application of novel nano-thermal and imaging techniques for monitoring drug microstructure and distribution within PLGA microspheres.                   International Journal of Pharmaceutics , 522  (1-2)   pp. 34-49.    10.1016/j.ijpharm.2017.02.056 <https://doi.org/10.1016/j.ijpharm.2017.02.056>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1542221/1/IJP%20Manuscript%2018022017.pdf