eprintid: 1541656
rev_number: 37
eprint_status: archive
userid: 608
dir: disk0/01/54/16/56
datestamp: 2017-02-19 06:26:31
lastmod: 2021-12-10 23:41:53
status_changed: 2017-03-09 10:58:47
type: article
metadata_visibility: show
creators_name: Carreno, G
creators_name: Gonzalez-Meljem, JM
creators_name: Haston, S
creators_name: Martinez-Barbera, JP
title: Stem cells and their role in pituitary tumorigenesis
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G22
keywords: Adamantinomatous craniopharyngioma, Cancer stem cell, Pituitary, Pituitary adenoma, Stem cell
note: Crown Copyright © 2016 Published by Elsevier Ireland Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0)
abstract: The presence of adult pituitary stem cells (PSCs) has been described in murine systems by comprehensive cellular profiling and genetic lineage tracing experiments. PSCs are thought to maintain multipotent capacity throughout life and give rise to all hormone-producing cell lineages, playing a role in pituitary gland homeostasis. Additionally, PSCs have been proposed to play a role in pituitary tumorigenesis, in both adenomas and adamantinomatous craniopharyngiomas. In this manuscript, we discuss the different approaches used to demonstrate the presence of PSCs in the murine adult pituitary, from marker analyses to genetic tracing. In addition, we review the published literature suggesting the existence of tumor stem cells in mouse and human pituitary tumors. Finally, we discuss the potential role of PSCs in pituitary tumorigenesis in the context of current models of carcinogenesis and present evidence showing that in contrast to pituitary adenoma, which follows a classical cancer stem cell paradigm, a novel mechanism has been revealed for paracrine, non-cell autonomous tumor initiation in adamantinomatous craniopharyngioma, a benign but clinically aggressive pediatric tumor.
date: 2017-04-15
date_type: published
official_url: http://dx.doi.org/10.1016/j.mce.2016.10.005
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1182716
doi: 10.1016/j.mce.2016.10.005
pii: S0303-7207(16)30413-0
lyricists_name: Carreno, Gabriela
lyricists_name: Gonzalez Meljem, Jose
lyricists_name: Haston, Scott
lyricists_name: Martinez-Barbera, Juan
lyricists_id: GACAR02
lyricists_id: GONZL17
lyricists_id: SHAST33
lyricists_id: JPMAR49
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Molecular and Cellular Endocrinology
volume: 445
pagerange: 27-34
event_location: Ireland
issn: 1872-8057
citation:        Carreno, G;    Gonzalez-Meljem, JM;    Haston, S;    Martinez-Barbera, JP;      (2017)    Stem cells and their role in pituitary tumorigenesis.                   Molecular and Cellular Endocrinology , 445    pp. 27-34.    10.1016/j.mce.2016.10.005 <https://doi.org/10.1016/j.mce.2016.10.005>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1541656/1/Carreno_Stem_cells.pdf