eprintid: 1540763
rev_number: 52
eprint_status: archive
userid: 608
dir: disk0/01/54/07/63
datestamp: 2017-02-11 22:59:07
lastmod: 2021-10-04 01:07:36
status_changed: 2017-08-11 10:34:25
type: article
metadata_visibility: show
creators_name: Thomas, JDJ
creators_name: Dattani, A
creators_name: Zemrak, F
creators_name: Burchell, T
creators_name: Akker, SA
creators_name: Kaplan, FJL
creators_name: Khoo, B
creators_name: Aylwin, S
creators_name: Grossman, AB
creators_name: Davies, LC
creators_name: Korbonits, M
title: Renin-Angiotensin System Blockade Improves Cardiac Indices in Acromegaly Patients
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G93
keywords: pituitary, acromegaly, cardiac magnetic resonance, renin-angiotensin
note: Available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) licence (https://creativecommons.org/licenses/by-nc-sa/4.0/).
abstract: PURPOSE: Blockade of the angiotensin-renin system, with angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs), has been shown to improve cardiac outcomes following myocardial infarction and delay progression of heart failure. Acromegaly is associated with a disease-specific cardiomyopathy, the pathogenesis of which is poorly understood.

METHODS: The cardiac indices of patients with active acromegaly with no hypertension (Group A, n=4), established hypertension not taking ACEi/ARBs (Group B, n=4) and established hypertension taking ACEi/ARBs (Group C, n=4) were compared using cardiac magnetic imaging.

RESULTS: Patients taking ACEi/ARBs had lower end diastolic volume index (EDVi) and end systolic volume index (ESVi) than the other 2 groups ([C] 73.24 vs. [A] 97.92 vs. [B] 101.03 ml/m2, ANOVA p=0.034, B vs. C p<0.01). Groups A and B had EDVi and ESVi values at the top of published reference range values; Group C had values in the middle of the range.

CONCLUSIONS: Acromegaly patients on ACEi/ARBs for hypertension demonstrate improved cardiac indices compared to acromegaly patients with hypertension not taking these medications. Further studies are needed to determine if these drugs have a beneficial cardiac effect in acromegaly in the absence of demonstrable hypertension.
date: 2017-06
date_type: published
official_url: http://dx.doi.org/10.1055/s-0042-123710
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1207742
doi: 10.1055/s-0042-123710
lyricists_name: Khoo, Bernard
lyricists_id: BKHOO30
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Experimental and Clinical Endocrinology & Diabetes
volume: 125
number: 6
pagerange: 365-367
event_location: Germany
issn: 1439-3646
citation:        Thomas, JDJ;    Dattani, A;    Zemrak, F;    Burchell, T;    Akker, SA;    Kaplan, FJL;    Khoo, B;                 ... Korbonits, M; + view all <#>        Thomas, JDJ;  Dattani, A;  Zemrak, F;  Burchell, T;  Akker, SA;  Kaplan, FJL;  Khoo, B;  Aylwin, S;  Grossman, AB;  Davies, LC;  Korbonits, M;   - view fewer <#>    (2017)    Renin-Angiotensin System Blockade Improves Cardiac Indices in Acromegaly Patients.                   Experimental and Clinical Endocrinology & Diabetes , 125  (6)   pp. 365-367.    10.1055/s-0042-123710 <https://doi.org/10.1055/s-0042-123710>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1540763/1/Thomas_Renin-Angiotensin_System_VoR.pdf