TY  - JOUR
N2  - The cell-surface glycoprotein CD56 has three major isoforms that play important roles in cell adhesion and signaling, which may promote cell proliferation, differentiation, survival, or migration. It is an important molecule in normal kidney development and acts as a key marker in Wilms tumor stem and progenitor cells. Here, we review the structural and genetic features of the CD56 glycoprotein, and summarize its roles in the normal versus diseased metanephric blastema. We discuss areas of CD56-related research that may complement or improve existing Wilms tumor treatment strategies, including the antibody-drug conjugate lorvotuzumab mertansine that binds to CD56.
ID  - discovery1540602
KW  - CD56
KW  -  NCAM-1
KW  -  Kidney development
KW  -  Wilms tumor
KW  -  Blastema
KW  -  Lorvotuzumab mertansine
TI  - Role of CD56 in Normal Kidney Development and Wilms Tumorigenesis
AV  - public
Y1  - 2017///
EP  - 75
UR  - http://dx.doi.org/10.1080/15513815.2016.1256358
SN  - 1551-3815
JF  - Fetal and Pediatric Pathology
A1  - Yap, L-W
A1  - Brok, J
A1  - Pritchard-Jones, K
SP  - 62
VL  - 36
IS  - 1
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
ER  -