eprintid: 1540293 rev_number: 32 eprint_status: archive userid: 608 dir: disk0/01/54/02/93 datestamp: 2017-02-13 15:07:10 lastmod: 2021-12-10 01:12:54 status_changed: 2017-02-13 15:07:10 type: article metadata_visibility: show creators_name: Woodhall, SC creators_name: Wills, GS creators_name: Horner, PJ creators_name: Craig, R creators_name: Mindell, JS creators_name: Murphy, G creators_name: McClure, MO creators_name: Soldan, K creators_name: Nardone, A creators_name: Johnson, AM title: Chlamydia trachomatis Pgp3 Antibody Population Seroprevalence before and during an Era of Widespread Opportunistic Chlamydia Screening in England (1994-2012) ispublished: pub divisions: UCL divisions: B02 divisions: D01 divisions: G16 divisions: D12 divisions: G19 note: Copyright: © 2017 Woodhall et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. abstract: BACKGROUND: Opportunistic chlamydia screening of <25 year-olds was nationally-implemented in England in 2008 but its impact on chlamydia transmission is poorly understood. We undertook a population-based seroprevalence study to explore the impact of screening on cumulative incidence of chlamydia, as measured by C.trachomatis-specific antibody. METHODS: Anonymised sera from participants in the nationally-representative Health Surveys for England (HSE) were tested for C.trachomatis antibodies using two novel Pgp3 enzyme-linked immunosorbent assays (ELISAs) as a marker of past infection. Determinants of being seropositive were explored using logistic regression among 16-44 year-old women and men in 2010 and 2012 (years when sexual behaviour questions were included in the survey) (n = 1,402 women; 1,119 men). Seroprevalence trends among 16-24 year-old women (n = 3,361) were investigated over ten time points from 1994-2012. RESULTS: In HSE2010/2012, Pgp3 seroprevalence among 16-44 year-olds was 24.4% (95%CI 22.0-27.1) in women and 13.9% (11.8-16.2) in men. Seroprevalence increased with age (up to 33.5% [27.5-40.2] in 30-34 year-old women, 18.7% [13.4-25.6] in 35-39 year-old men); years since first sex; number of lifetime sexual partners; and younger age at first sex. 76.7% of seropositive 16-24 year-olds had never been diagnosed with chlamydia. Among 16-24 year-old women, a non-significant decline in seroprevalence was observed from 2008-2012 (prevalence ratio per year: 0.94 [0.84-1.05]). CONCLUSION: Our application of Pgp3 ELISAs demonstrates a high lifetime risk of chlamydia infection among women and a large proportion of undiagnosed infections. A decrease in age-specific cumulative incidence following national implementation of opportunistic chlamydia screening has not yet been demonstrated. We propose these assays be used to assess impact of chlamydia control programmes. date: 2017-01-27 date_type: published official_url: http://dx.doi.org/10.1371/journal.pone.0152810 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1206047 doi: 10.1371/journal.pone.0152810 pii: PONE-D-15-51000 lyricists_name: Johnson, Anne lyricists_name: Mindell, Jennifer lyricists_id: AMJOH29 lyricists_id: JMIND63 actors_name: Bracey, Alan actors_id: ABBRA90 actors_role: owner full_text_status: public publication: PLoS One volume: 12 number: 1 article_number: e0152810 event_location: United States issn: 1932-6203 citation: Woodhall, SC; Wills, GS; Horner, PJ; Craig, R; Mindell, JS; Murphy, G; McClure, MO; ... Johnson, AM; + view all <#> Woodhall, SC; Wills, GS; Horner, PJ; Craig, R; Mindell, JS; Murphy, G; McClure, MO; Soldan, K; Nardone, A; Johnson, AM; - view fewer <#> (2017) Chlamydia trachomatis Pgp3 Antibody Population Seroprevalence before and during an Era of Widespread Opportunistic Chlamydia Screening in England (1994-2012). PLoS One , 12 (1) , Article e0152810. 10.1371/journal.pone.0152810 <https://doi.org/10.1371/journal.pone.0152810>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1540293/1/journal.pone.0152810.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/1540293/7/Woodhall_Chlamydia%20trachomatis_Supp1.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/1540293/8/Woodhall_Chlamydia%20trachomatis_Supp2.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/1540293/9/Woodhall_Chlamydia%20trachomatis_Supp3.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/1540293/10/Woodhall_Chlamydia%20trachomatis_Figure.pdf