eprintid: 1538771
rev_number: 30
eprint_status: archive
userid: 608
dir: disk0/01/53/87/71
datestamp: 2017-02-02 09:53:57
lastmod: 2021-09-20 22:26:02
status_changed: 2017-10-04 11:09:51
type: article
metadata_visibility: show
creators_name: Yang, G-Z
creators_name: Li, J-J
creators_name: Yu, D-G
creators_name: He, M-F
creators_name: Yang, J-H
creators_name: Williams, GR
title: Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: Nanoscale drug depot; sustained release; cellulose acetate; tri-axial electrospinning; core-shell nanostructure
note: © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher.
abstract: Nanoscale drug depots, comprising a drug reservoir surrounded by a carrier membrane, are much sought after in contemporary pharmaceutical research. Using cellulose acetate (CA) as a filament-forming polymeric matrix and ferulic acid (FA) as a model drug, nanoscale drug depots in the form of core-shell fibers were designed and fabricated using a modified tri-axial electrospinning process. This employed a solvent mixture as the outer working fluid, as a result of which a robust and continuous preparation process could be achieved. The fiber-based depots had a linear morphology, smooth surfaces, and an average diameter of 0.62 ± 0.07 μm. Electron microscopy data showed them to have clear core-shell structures, with the FA encapsulated inside a CA shell. X-ray diffraction and IR spectroscopy results verified that FA was present in the crystalline physical form. In vitro dissolution tests revealed that the fibers were able to provide close to zero-order release over 36 h, with no initial burst release and minimal tailing-off. The release properties of the depot systems were much improved over monolithic CA/FA fibers, which exhibited a significant burst release and also considerable tailing-off at the end of the release experiment. Here we thus demonstrate the concept of using modified tri-axial electrospinning to design and develop new types of heterogeneous nanoscale biomaterials.
date: 2017-01-27
date_type: published
official_url: http://doi.org/10.1016/j.actbio.2017.01.069
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1206161
doi: 10.1016/j.actbio.2017.01.069
lyricists_name: Williams, Gareth
lyricists_id: GWILL02
actors_name: Williams, Gareth
actors_id: GWILL02
actors_role: owner
full_text_status: public
publication: Acta Biomaterialia
volume: 53
pagerange: 233-241
issn: 1742-7061
citation:        Yang, G-Z;    Li, J-J;    Yu, D-G;    He, M-F;    Yang, J-H;    Williams, GR;      (2017)    Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning.                   Acta Biomaterialia , 53    pp. 233-241.    10.1016/j.actbio.2017.01.069 <https://doi.org/10.1016/j.actbio.2017.01.069>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1538771/1/Williams_GRW%20Acta%20Biomater%202017%20-%20accepted%20MS.pdf