<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1538588> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/title> "DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/abstract> "Parkinson's disease is a neurodegenerative disorder characterized by the death of dopaminergic neurons and by accumulation of alpha-synuclein (aS) aggregates in the surviving neurons. The dopamine catabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) is a highly reactive and toxic molecule that leads to aS oligomerization by covalent modifications to lysine residues. Here we show that DOPAL-induced aS oligomer formation in neurons is associated with damage of synaptic vesicles, and with alterations in the synaptic vesicles pools. To investigate the molecular mechanism that leads to synaptic impairment, we first aimed to characterize the biochemical and biophysical properties of the aS-DOPAL oligomers; heterogeneous ensembles of macromolecules able to permeabilise cholesterol-containing lipid membranes. aS-DOPAL oligomers can induce dopamine leak in an in vitro model of synaptic vesicles and in cellular models. The dopamine released, after conversion to DOPAL in the cytoplasm, could trigger a noxious cycle that further fuels the formation of aS-DOPAL oligomers, inducing neurodegeneration."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/date> "2017-01-13" . <https://discovery.ucl.ac.uk/id/document/330046> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/volume> "7" . <https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://xmlns.com/foaf/0.1/name> "Scientific Reports"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-20452322> . <https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:20452322> . <https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://purl.org/ontology/bibo/issn> "20452322" . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-70518797717a56106c9516f87df820b2> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-70518797717a56106c9516f87df820b2> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-18de6625127cc7749d3a439e9619ab6a> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-18de6625127cc7749d3a439e9619ab6a> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fc2c0f40dc068f854a73a61f5132d049> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-fc2c0f40dc068f854a73a61f5132d049> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3c876ea67e4832c658a527d07a6fd4ed> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-3c876ea67e4832c658a527d07a6fd4ed> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-311df86715127d8d99d51581044e96d3> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-311df86715127d8d99d51581044e96d3> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-613883970fd9d5f6908b6fdc8ea8a2be> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-613883970fd9d5f6908b6fdc8ea8a2be> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-55832eba4bcfe9b0c2588c1ff5b92f13> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-55832eba4bcfe9b0c2588c1ff5b92f13> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ed9b1f8dde4d0d90cf15ea0dc7e1e756> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-ed9b1f8dde4d0d90cf15ea0dc7e1e756> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6a93ad7e815d2290a2bee28ff6599e55> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-6a93ad7e815d2290a2bee28ff6599e55> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8771394529e2323a8a92bb5113d10421> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-8771394529e2323a8a92bb5113d10421> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-db401e50f86ac5bd1e5870e66d153247> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-db401e50f86ac5bd1e5870e66d153247> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9206b73825ff9593c622836ab0e58588> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-9206b73825ff9593c622836ab0e58588> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-69fd2f1332774ed736cdf07ef3a9f7ca> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-69fd2f1332774ed736cdf07ef3a9f7ca> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1d6172d0db9b28e186b35d4af932596a> . <https://discovery.ucl.ac.uk/id/eprint/1538588> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> . <https://discovery.ucl.ac.uk/id/eprint/1538588#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-1d6172d0db9b28e186b35d4af932596a> . <https://discovery.ucl.ac.uk/id/person/ext-55832eba4bcfe9b0c2588c1ff5b92f13> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-55832eba4bcfe9b0c2588c1ff5b92f13> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-55832eba4bcfe9b0c2588c1ff5b92f13> <http://xmlns.com/foaf/0.1/familyName> "Greggio"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-55832eba4bcfe9b0c2588c1ff5b92f13> <http://xmlns.com/foaf/0.1/name> "E Greggio"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8771394529e2323a8a92bb5113d10421> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8771394529e2323a8a92bb5113d10421> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8771394529e2323a8a92bb5113d10421> <http://xmlns.com/foaf/0.1/familyName> "Girotto"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8771394529e2323a8a92bb5113d10421> <http://xmlns.com/foaf/0.1/name> "S Girotto"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6a93ad7e815d2290a2bee28ff6599e55> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-6a93ad7e815d2290a2bee28ff6599e55> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6a93ad7e815d2290a2bee28ff6599e55> <http://xmlns.com/foaf/0.1/familyName> "Veronesi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6a93ad7e815d2290a2bee28ff6599e55> <http://xmlns.com/foaf/0.1/name> "M Veronesi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-311df86715127d8d99d51581044e96d3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-311df86715127d8d99d51581044e96d3> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-311df86715127d8d99d51581044e96d3> <http://xmlns.com/foaf/0.1/familyName> "Zanetti"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-311df86715127d8d99d51581044e96d3> <http://xmlns.com/foaf/0.1/name> "M Zanetti"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9206b73825ff9593c622836ab0e58588> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9206b73825ff9593c622836ab0e58588> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9206b73825ff9593c622836ab0e58588> <http://xmlns.com/foaf/0.1/familyName> "Perego"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9206b73825ff9593c622836ab0e58588> <http://xmlns.com/foaf/0.1/name> "C Perego"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1d6172d0db9b28e186b35d4af932596a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1d6172d0db9b28e186b35d4af932596a> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1d6172d0db9b28e186b35d4af932596a> <http://xmlns.com/foaf/0.1/familyName> "Bubacco"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1d6172d0db9b28e186b35d4af932596a> <http://xmlns.com/foaf/0.1/name> "L Bubacco"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-69fd2f1332774ed736cdf07ef3a9f7ca> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-69fd2f1332774ed736cdf07ef3a9f7ca> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-69fd2f1332774ed736cdf07ef3a9f7ca> <http://xmlns.com/foaf/0.1/familyName> "Casella"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-69fd2f1332774ed736cdf07ef3a9f7ca> <http://xmlns.com/foaf/0.1/name> "L Casella"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-613883970fd9d5f6908b6fdc8ea8a2be> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-613883970fd9d5f6908b6fdc8ea8a2be> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-613883970fd9d5f6908b6fdc8ea8a2be> <http://xmlns.com/foaf/0.1/familyName> "Lunelli"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-613883970fd9d5f6908b6fdc8ea8a2be> <http://xmlns.com/foaf/0.1/name> "L Lunelli"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ed9b1f8dde4d0d90cf15ea0dc7e1e756> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . 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