eprintid: 1536480
rev_number: 49
eprint_status: archive
userid: 608
dir: disk0/01/53/64/80
datestamp: 2017-01-21 21:03:00
lastmod: 2021-09-21 22:10:56
status_changed: 2017-02-23 15:07:25
type: article
metadata_visibility: show
creators_name: Palesi, F
creators_name: Tournier, JD
creators_name: Calamante, F
creators_name: Muhlert, N
creators_name: Castellazzi, G
creators_name: Chard, D
creators_name: D'Angelo, E
creators_name: Wheeler-Kingshott, CG
title: Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F87
keywords: Cerebello-thalamo-cortical pathway, constrained spherical deconvolution, diffusion MRI, super-resolution, trackdensity imaging
note: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to thecerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (b0). We observed that the reconstruction of the pathways was more anatomically accurate when using ROIs placed on TDI rather than on b0 maps, while inter-subject variability and reproducibility were similar between the two methods. Diffusion indices along pathways showed a position-dependent specificity that will need to be taken into consideration in future clinical investigations.
date: 2016-10
official_url: http://dx.doi.org/10.11138/FNeur/2016.31.4.229
oa_status: green
full_text_type: pub
pmcid: PMC5231885
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1201628
doi: 10.11138/FNeur/2016.31.4.229
pii: 7506
lyricists_name: Castellazzi, Gloria
lyricists_name: Chard, Declan
lyricists_name: Wheeler-Kingshott, Claudia
lyricists_id: GCAST91
lyricists_id: DTCHA57
lyricists_id: CWHEE14
actors_name: Wheeler-Kingshott, Claudia
actors_name: Holmes, Tina
actors_id: CWHEE14
actors_id: TDHOL52
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Functional Neurology
volume: 31
number: 4
pagerange: 229-238
event_location: Italy
issn: 1971-3274
citation:        Palesi, F;    Tournier, JD;    Calamante, F;    Muhlert, N;    Castellazzi, G;    Chard, D;    D'Angelo, E;           Palesi, F;  Tournier, JD;  Calamante, F;  Muhlert, N;  Castellazzi, G;  Chard, D;  D'Angelo, E;  Wheeler-Kingshott, CG;   - view fewer <#>    (2016)    Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction.                   Functional Neurology , 31  (4)   pp. 229-238.    10.11138/FNeur/2016.31.4.229 <https://doi.org/10.11138/FNeur%2F2016.31.4.229>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1536480/10/Wheeler-Kingshott_article.pdf
document_url: https://discovery.ucl.ac.uk/id/eprint/1536480/15/drive-download-20170223T144217Z-001.zip