eprintid: 1536480 rev_number: 49 eprint_status: archive userid: 608 dir: disk0/01/53/64/80 datestamp: 2017-01-21 21:03:00 lastmod: 2021-09-21 22:10:56 status_changed: 2017-02-23 15:07:25 type: article metadata_visibility: show creators_name: Palesi, F creators_name: Tournier, JD creators_name: Calamante, F creators_name: Muhlert, N creators_name: Castellazzi, G creators_name: Chard, D creators_name: D'Angelo, E creators_name: Wheeler-Kingshott, CG title: Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F87 keywords: Cerebello-thalamo-cortical pathway, constrained spherical deconvolution, diffusion MRI, super-resolution, trackdensity imaging note: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. abstract: The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to thecerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (b0). We observed that the reconstruction of the pathways was more anatomically accurate when using ROIs placed on TDI rather than on b0 maps, while inter-subject variability and reproducibility were similar between the two methods. Diffusion indices along pathways showed a position-dependent specificity that will need to be taken into consideration in future clinical investigations. date: 2016-10 official_url: http://dx.doi.org/10.11138/FNeur/2016.31.4.229 oa_status: green full_text_type: pub pmcid: PMC5231885 language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1201628 doi: 10.11138/FNeur/2016.31.4.229 pii: 7506 lyricists_name: Castellazzi, Gloria lyricists_name: Chard, Declan lyricists_name: Wheeler-Kingshott, Claudia lyricists_id: GCAST91 lyricists_id: DTCHA57 lyricists_id: CWHEE14 actors_name: Wheeler-Kingshott, Claudia actors_name: Holmes, Tina actors_id: CWHEE14 actors_id: TDHOL52 actors_role: owner actors_role: impersonator full_text_status: public publication: Functional Neurology volume: 31 number: 4 pagerange: 229-238 event_location: Italy issn: 1971-3274 citation: Palesi, F; Tournier, JD; Calamante, F; Muhlert, N; Castellazzi, G; Chard, D; D'Angelo, E; Palesi, F; Tournier, JD; Calamante, F; Muhlert, N; Castellazzi, G; Chard, D; D'Angelo, E; Wheeler-Kingshott, CG; - view fewer <#> (2016) Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction. Functional Neurology , 31 (4) pp. 229-238. 10.11138/FNeur/2016.31.4.229 <https://doi.org/10.11138/FNeur%2F2016.31.4.229>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1536480/10/Wheeler-Kingshott_article.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/1536480/15/drive-download-20170223T144217Z-001.zip