TY - JOUR N1 - This version is the version of record. For information on re-use, please refer to the publisher?s terms and conditions. ID - discovery1536480 UR - http://dx.doi.org/10.11138/FNeur/2016.31.4.229 JF - Functional Neurology SP - 229 SN - 1971-3274 N2 - The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to thecerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (b0). We observed that the reconstruction of the pathways was more anatomically accurate when using ROIs placed on TDI rather than on b0 maps, while inter-subject variability and reproducibility were similar between the two methods. Diffusion indices along pathways showed a position-dependent specificity that will need to be taken into consideration in future clinical investigations. AV - public TI - Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction Y1 - 2016/10// VL - 31 EP - 238 A1 - Palesi, F A1 - Tournier, JD A1 - Calamante, F A1 - Muhlert, N A1 - Castellazzi, G A1 - Chard, D A1 - D'Angelo, E A1 - Wheeler-Kingshott, CG KW - Cerebello-thalamo-cortical pathway KW - constrained spherical deconvolution KW - diffusion MRI KW - super-resolution KW - trackdensity imaging IS - 4 ER -