TY  - JOUR
PB  - SPRINGER
Y1  - 2016/12//
A1  - Perner, A
A1  - Gordon, AC
A1  - De Backer, D
A1  - Dimopoulos, G
A1  - Russell, JA
A1  - Lipman, J
A1  - Jensen, J-U
A1  - Myburgh, J
A1  - Singer, M
A1  - Bellomo, R
A1  - Walsh, T
IS  - 12
VL  - 42
N2  - Sepsis is a major growing global burden and a major challenge to intensive care clinicians, researchers, guideline committee members and policy makers, because of its high and increasing incidence and great pathophysiological, molecular, genetic and clinical complexity. In spite of recent progress, short-term mortality remains high and there is growing evidence of long-term morbidity and increased long-term mortality in survivors of sepsis both in developed and developing countries. Further improvement in the care of patients with sepsis will impact upon global health. In this narrative review, invited experts describe the expected challenges and progress to be made in the near future. We focus on diagnosis, resuscitation (fluids, vasopressors, inotropes, blood transfusion and hemodynamic targets) and infection (antibiotics and infection biomarkers), as these areas are key, if initial management and subsequent outcomes are to be improved in patients with sepsis.
EP  - 1969
JF  - Intensive Care Medicine
AV  - public
ID  - discovery1536318
SN  - 0342-4642
N1  - © Springer-Verlag Berlin Heidelberg and ESICM 2016.
The final publication is available at Springer via http://dx.doi.org/10.1007/s00134-016-4577-z.
TI  - Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Critical Care Medicine
KW  -  General & Internal Medicine
KW  -  Sepsis
KW  -  Critical care
KW  -  Intensive care
KW  -  Shock
KW  -  Antibiotic
KW  -  Trial Sequential-analysis
KW  -  Critically-ill Patients
KW  -  International Consensus Definitions
KW  -  Randomized Clinical-trial
KW  -  Septic Shock Sepsis-3
KW  -  Blood-cell Transfusion
KW  -  Goal-directed Therapy
KW  -  Intensive-care Units
KW  -  Acute Kidney Injury
KW  -  Hydroxyethyl Starch
UR  - http://doi.org/10.1007/s00134-016-4577-z
SP  - 1958
ER  -