%0 Journal Article
%@ 0342-4642
%A Perner, A
%A Gordon, AC
%A De Backer, D
%A Dimopoulos, G
%A Russell, JA
%A Lipman, J
%A Jensen, J-U
%A Myburgh, J
%A Singer, M
%A Bellomo, R
%A Walsh, T
%D 2016
%F discovery:1536318
%I SPRINGER
%J Intensive Care Medicine
%K Science & Technology, Life Sciences & Biomedicine, Critical Care Medicine, General & Internal Medicine, Sepsis, Critical care, Intensive care, Shock, Antibiotic, Trial Sequential-analysis, Critically-ill Patients, International Consensus Definitions, Randomized Clinical-trial, Septic Shock Sepsis-3, Blood-cell Transfusion, Goal-directed Therapy, Intensive-care Units, Acute Kidney Injury, Hydroxyethyl Starch
%N 12
%P 1958-1969
%T Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy
%U https://discovery.ucl.ac.uk/id/eprint/1536318/
%V 42
%X Sepsis is a major growing global burden and a major challenge to intensive care clinicians, researchers, guideline committee members and policy makers, because of its high and increasing incidence and great pathophysiological, molecular, genetic and clinical complexity. In spite of recent progress, short-term mortality remains high and there is growing evidence of long-term morbidity and increased long-term mortality in survivors of sepsis both in developed and developing countries. Further improvement in the care of patients with sepsis will impact upon global health. In this narrative review, invited experts describe the expected challenges and progress to be made in the near future. We focus on diagnosis, resuscitation (fluids, vasopressors, inotropes, blood transfusion and hemodynamic targets) and infection (antibiotics and infection biomarkers), as these areas are key, if initial management and subsequent outcomes are to be improved in patients with sepsis.
%Z © Springer-Verlag Berlin Heidelberg and ESICM 2016.  The final publication is available at Springer via http://dx.doi.org/10.1007/s00134-016-4577-z.