eprintid: 1535936
rev_number: 29
eprint_status: archive
userid: 608
dir: disk0/01/53/59/36
datestamp: 2017-01-14 23:13:04
lastmod: 2021-09-26 22:52:14
status_changed: 2017-02-24 10:49:21
type: article
metadata_visibility: show
creators_name: Charidimou, A
creators_name: Schmitt, A
creators_name: Wilson, D
creators_name: Yakushiji, Y
creators_name: Gregoire, SM
creators_name: Fox, Z
creators_name: Jäger, HR
creators_name: Werring, DJ
title: The Cerebral Haemorrhage Anatomical RaTing inStrument (CHARTS): Development and assessment of reliability.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F82
keywords: CT, Cerebral amyloid angiopathy, Intracerebral haemorrhage, MRI, Stroke
note: Copyright © 2017 Elsevier Ltd. All rights reserved. This is an Open Access article made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher.
abstract: PURPOSE: The causes, risk factors and prognosis of spontaneous intracerebral haemorrhage (ICH) are partly determined by anatomical location (specifically, lobar vs. non-lobar (deep and infratentorial) regions). We systematically developed a rating instrument to reliably classify ICH location. METHODS: We used a two-stage iterative Delphi-style method for instrument development. The resultant Cerebral Haemorrhage Anatomical RaTing inStrument (CHARTS) was validated on CT and MRI scans from a cohort of consecutive patients with acute spontaneous symptomatic ICH by three independent raters. We tested interrater and intrarater reliability using kappa statistics. RESULTS: Our validation cohort included 227 patients (58% male; median age: 72.4 (IQR: 67.1-74.6)). The interrater reliability for the main analyses (i.e. including any lobar ICH; all deep and infratentorial anatomical categories (lentiform, caudate thalamus; brainstem; cerebellum); and uncertain location) was excellent (all kappa values>0.80) both in pair-wise between-rater comparisons and across all raters. The intrarater reliability was substantial to almost perfect (k=0.83; 95%CI: 0.77-0.88 and k=0.95; 95%CI: 0.92-0.96 respectively). All kappa statistics remained consistent for individual cerebral lobar regions. CONCLUSIONS: The CHARTS instrument can be used to reliably and comprehensively map the anatomical location of spontaneous ICH, and may be helpful for studying important questions regarding causes, risk factors, prognosis, and for stratification in clinical trials.
date: 2016-11-12
date_type: published
official_url: http://doi.org/10.1016/j.jns.2016.11.021
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1196577
doi: 10.1016/j.jns.2016.11.021
pii: S0022-510X(16)30716-X
lyricists_name: Jager, Hans
lyricists_name: Werring, David
lyricists_name: Wilson, Duncan
lyricists_id: HRJAG57
lyricists_id: DJWER24
lyricists_id: DWILS37
full_text_status: public
publication: Journal of the Neurological Sciences
volume: 372
pagerange: 178-183
event_location: Netherlands
issn: 1878-5883
citation:        Charidimou, A;    Schmitt, A;    Wilson, D;    Yakushiji, Y;    Gregoire, SM;    Fox, Z;    Jäger, HR;           Charidimou, A;  Schmitt, A;  Wilson, D;  Yakushiji, Y;  Gregoire, SM;  Fox, Z;  Jäger, HR;  Werring, DJ;   - view fewer <#>    (2016)    The Cerebral Haemorrhage Anatomical RaTing inStrument (CHARTS): Development and assessment of reliability.                   Journal of the Neurological Sciences , 372    pp. 178-183.    10.1016/j.jns.2016.11.021 <https://doi.org/10.1016/j.jns.2016.11.021>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1535936/1/Werring_The%20Cerebral%20Haemorrhage%20Anatomical_.pdf