eprintid: 1535936 rev_number: 29 eprint_status: archive userid: 608 dir: disk0/01/53/59/36 datestamp: 2017-01-14 23:13:04 lastmod: 2021-09-26 22:52:14 status_changed: 2017-02-24 10:49:21 type: article metadata_visibility: show creators_name: Charidimou, A creators_name: Schmitt, A creators_name: Wilson, D creators_name: Yakushiji, Y creators_name: Gregoire, SM creators_name: Fox, Z creators_name: Jäger, HR creators_name: Werring, DJ title: The Cerebral Haemorrhage Anatomical RaTing inStrument (CHARTS): Development and assessment of reliability. ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F82 keywords: CT, Cerebral amyloid angiopathy, Intracerebral haemorrhage, MRI, Stroke note: Copyright © 2017 Elsevier Ltd. All rights reserved. This is an Open Access article made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher. abstract: PURPOSE: The causes, risk factors and prognosis of spontaneous intracerebral haemorrhage (ICH) are partly determined by anatomical location (specifically, lobar vs. non-lobar (deep and infratentorial) regions). We systematically developed a rating instrument to reliably classify ICH location. METHODS: We used a two-stage iterative Delphi-style method for instrument development. The resultant Cerebral Haemorrhage Anatomical RaTing inStrument (CHARTS) was validated on CT and MRI scans from a cohort of consecutive patients with acute spontaneous symptomatic ICH by three independent raters. We tested interrater and intrarater reliability using kappa statistics. RESULTS: Our validation cohort included 227 patients (58% male; median age: 72.4 (IQR: 67.1-74.6)). The interrater reliability for the main analyses (i.e. including any lobar ICH; all deep and infratentorial anatomical categories (lentiform, caudate thalamus; brainstem; cerebellum); and uncertain location) was excellent (all kappa values>0.80) both in pair-wise between-rater comparisons and across all raters. The intrarater reliability was substantial to almost perfect (k=0.83; 95%CI: 0.77-0.88 and k=0.95; 95%CI: 0.92-0.96 respectively). All kappa statistics remained consistent for individual cerebral lobar regions. CONCLUSIONS: The CHARTS instrument can be used to reliably and comprehensively map the anatomical location of spontaneous ICH, and may be helpful for studying important questions regarding causes, risk factors, prognosis, and for stratification in clinical trials. date: 2016-11-12 date_type: published official_url: http://doi.org/10.1016/j.jns.2016.11.021 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1196577 doi: 10.1016/j.jns.2016.11.021 pii: S0022-510X(16)30716-X lyricists_name: Jager, Hans lyricists_name: Werring, David lyricists_name: Wilson, Duncan lyricists_id: HRJAG57 lyricists_id: DJWER24 lyricists_id: DWILS37 full_text_status: public publication: Journal of the Neurological Sciences volume: 372 pagerange: 178-183 event_location: Netherlands issn: 1878-5883 citation: Charidimou, A; Schmitt, A; Wilson, D; Yakushiji, Y; Gregoire, SM; Fox, Z; Jäger, HR; Charidimou, A; Schmitt, A; Wilson, D; Yakushiji, Y; Gregoire, SM; Fox, Z; Jäger, HR; Werring, DJ; - view fewer <#> (2016) The Cerebral Haemorrhage Anatomical RaTing inStrument (CHARTS): Development and assessment of reliability. Journal of the Neurological Sciences , 372 pp. 178-183. 10.1016/j.jns.2016.11.021 <https://doi.org/10.1016/j.jns.2016.11.021>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1535936/1/Werring_The%20Cerebral%20Haemorrhage%20Anatomical_.pdf