eprintid: 1535930
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/01/53/59/30
datestamp: 2017-01-14 23:12:40
lastmod: 2020-02-12 16:00:23
status_changed: 2017-01-17 09:24:40
type: article
metadata_visibility: show
creators_name: Zhao, C
creators_name: Vassiljev, N
creators_name: Konstantinidis, A
creators_name: Speller, R
creators_name: Kanicki, J
title: Three-dimensional cascaded system analysis of a 50 µm pixel pitch wafer-scale CMOS active pixel sensor x-ray detector for digital breast tomosynthesis
ispublished: pub
divisions: UCL
divisions: A01
divisions: B04
divisions: C05
divisions: F42
keywords: CMOS active pixel sensor, cascaded system analysis, detective quantum efficiency, digital breast tomosynthesis, pixelated scintillator, three-dimensional, x-ray detector
note: © Copyright 2017 IOP Publishing
abstract: High-resolution, low-noise x-ray detectors based on the complementary metal-oxide-semiconductor (CMOS) active pixel sensor (APS) technology have been developed and proposed for digital breast tomosynthesis (DBT). In this study, we evaluated the three-dimensional (3D) imaging performance of a 50 ��m pixel pitch CMOS APS x-ray detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). The two-dimensional (2D) angle-dependent modulation transfer function (MTF), normalized noise power spectrum (NNPS), and detective quantum efficiency (DQE) were experimentally characterized and modeled using the cascaded system analysis at oblique incident angles up to 30��. The cascaded system model was extended to the 3D spatial frequency space in combination with the filtered back-projection (FBP) reconstruction method to calculate the 3D and in-plane MTF, NNPS and DQE parameters. The results demonstrate that the beam obliquity blurs the 2D MTF and DQE in the high spatial frequency range. However, this effect can be eliminated after FBP image reconstruction. In addition, impacts of the image acquisition geometry and detector parameters were evaluated using the 3D cascaded system analysis for DBT. The result shows that a wider projection angle range (e.g. ��30��) improves the low spatial frequency (below 5 mm-1) performance of the CMOS APS detector. In addition, to maintain a high spatial resolution for DBT, a focal spot size of smaller than 0.3 mm should be used. Theoretical analysis suggests that a pixelated scintillator in combination with the 50 ��m pixel pitch CMOS APS detector could further improve the 3D image resolution. Finally, the 3D imaging performance of the CMOS APS and an indirect amorphous silicon (a-Si:H) thin-film transistor (TFT) passive pixel sensor (PPS) detector was simulated and compared.
date: 2017-03-07
date_type: published
official_url: http://dx.doi.org/10.1088/1361-6560/aa586c
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1201655
doi: 10.1088/1361-6560/aa586c
lyricists_name: Speller, Robert
lyricists_id: RDSPE08
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: Physics in Medicine & Biology
volume: 62
number: 5
pagerange: 1994-2017
event_location: England
issn: 1361-6560
citation:        Zhao, C;    Vassiljev, N;    Konstantinidis, A;    Speller, R;    Kanicki, J;      (2017)    Three-dimensional cascaded system analysis of a 50 µm pixel pitch wafer-scale CMOS active pixel sensor x-ray detector for digital breast tomosynthesis.                   Physics in Medicine & Biology , 62  (5)   pp. 1994-2017.    10.1088/1361-6560/aa586c <https://doi.org/10.1088/1361-6560%2Faa586c>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1535930/1/Zhao%2Bet%2Bal_2017_Phys._Med._Biol._10.1088_1361-6560_aa586c.pdf