eprintid: 153360
rev_number: 43
eprint_status: archive
userid: 608
dir: disk0/00/15/33/60
datestamp: 2010-10-29 18:55:40
lastmod: 2021-10-16 22:05:35
status_changed: 2010-10-29 18:55:40
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Zabaneh, D
creators_name: Balding, DJ
title: A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F99
keywords: LOCI, POPULATION, RISK, VARIANTS, DISEASE
note: © 2010 Zabaneh, Balding. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

D. Zabaneh and stage one and two genotyping were funded by the British Heart Foundation [SP/04/02]. The funders had no role in study design,
abstract: We conducted a two-stage genome-wide association study to identify common genetic variation altering risk of the metabolic syndrome and related phenotypes in Indian Asian men, who have a high prevalence of these conditions. In Stage 1, approximately 317,000 single nucleotide polymorphisms were genotyped in 2700 individuals, from which 1500 SNPs were selected to be genotyped in a further 2300 individuals. Selection for inclusion in Stage 1 was based on four metabolic syndrome component traits: HDL-cholesterol, plasma glucose and Type 2 diabetes, abdominal obesity measured by waist to hip ratio, and diastolic blood pressure. Association was tested with these four traits and a composite metabolic syndrome phenotype. Four SNPs reaching significance level p<5x10(-7) and with posterior probability of association >0.8 were found in genes CETP and LPL, associated with HDL-cholesterol. These associations have already been reported in Indian Asians and in Europeans. Five additional loci harboured SNPs significant at p<10(-6) and posterior probability >0.5 for HDL-cholesterol, type 2 diabetes or diastolic blood pressure. Our results suggest that the primary genetic determinants of metabolic syndrome are the same in Indian Asians as in other populations, despite the higher prevalence. Further, we found little evidence of a common genetic basis for metabolic syndrome traits in our sample of Indian Asian men.
date: 2010-08-04
publisher: PUBLIC LIBRARY SCIENCE
official_url: http://dx.doi.org/10.1371/journal.pone.0011961
vfaculties: VFLS
oa_status: green
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_batch
elements_source: Web of Science
elements_id: 252250
doi: 10.1371/journal.pone.0011961
language_elements: EN
lyricists_name: Balding, David
lyricists_name: Zabaneh, Delilah
lyricists_id: DJBAL01
lyricists_id: DMZAB47
full_text_status: public
publication: PLOS ONE
volume: 5
number: 8
article_number: e11961
issn: 1932-6203
citation:        Zabaneh, D;    Balding, DJ;      (2010)    A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men.                   PLOS ONE , 5  (8)    , Article e11961.  10.1371/journal.pone.0011961 <https://doi.org/10.1371/journal.pone.0011961>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/153360/1/153360.pdf