eprintid: 1532882
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/01/53/28/82
datestamp: 2016-12-23 15:17:44
lastmod: 2021-09-20 00:06:51
status_changed: 2016-12-23 15:17:44
type: article
metadata_visibility: show
creators_name: Tan, HM
creators_name: Wills, TJ
creators_name: Cacucci, F
title: The development of spatial and memory circuits in the rat
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F96
divisions: G02
note: This is the peer reviewed version of the following article: Tan, H. M., Wills, T. J. and Cacucci, F. (2016), The development of spatial and memory circuits in the rat. WIREs Cogn Sci. doi:10.1002/wcs.1424, which has been published in final form at http://dx.doi.org/10.1002/wcs.1424. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
abstract: We provide a concise review of recent studies related to the development of neural circuits supporting spatial navigation and memory in the rat. We chart the relative timeline of the emergence of the four main classes of spatially tuned neurons within the hippocampus and related limbic areas: head direction cells emerge earliest (postnatal day 12, P12), before the eyes of the rats are even open, followed by place cells and boundary responsive cells; grid cells emerge last, around the age of weaning (P21). The rate of maturation is unique to each type of neuron, with the head direction and grid cells showing rapid developmental spurts, in contrast to place cells, which show a more gradual trend of maturation. Interestingly, the emergence of allocentric spatial abilities occurs only after the full complement of spatial neurons becomes functional at P20-21, whereas associative processing in the place cell network is evident from as early as P16. We also present evidence supporting the view that the sensory inputs, which are particularly salient to adult spatial networks, may not be essential for the immature spatial system. Crucially, visual information, although more salient than other sensory modalities for anchoring the adult head direction system, does not appear to be essential for setting up the immature head direction network. We conclude by highlighting an urgent need for new theoretical models that can account for the sequential emergence of spatial cells, as well as the lack of primacy of vision in the early organization of the head direction network. For further resources related to this article, please visit the WIREs website.
date: 2017-05
date_type: published
official_url: http://dx.doi.org/10.1002/wcs.1424
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Review
verified: verified_manual
elements_id: 1196140
doi: 10.1002/wcs.1424
lyricists_name: Cacucci, Francesca
lyricists_name: Wills, Thomas
lyricists_id: FCACU14
lyricists_id: TJWIL19
actors_name: Cacucci, Francesca
actors_id: FCACU14
actors_role: owner
full_text_status: public
publication: Wiley Interdisciplinary Reviews: Cognitive Science
volume: 8
number: 3
article_number: e1424
event_location: United States
issn: 1939-5086
citation:        Tan, HM;    Wills, TJ;    Cacucci, F;      (2017)    The development of spatial and memory circuits in the rat.                   Wiley Interdisciplinary Reviews: Cognitive Science , 8  (3)    , Article e1424.  10.1002/wcs.1424 <https://doi.org/10.1002/wcs.1424>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1532882/1/tan%20wills%20cacucci%202016.pdf