eprintid: 1532670
rev_number: 33
eprint_status: archive
userid: 608
dir: disk0/01/53/26/70
datestamp: 2016-12-20 17:13:09
lastmod: 2021-09-20 00:32:53
status_changed: 2016-12-21 15:59:24
type: article
metadata_visibility: show
creators_name: Li, H
creators_name: Williams, GR
creators_name: Wu, J
creators_name: Lv, Y
creators_name: Sun, X
creators_name: Wu, H
creators_name: Zhu, LM
title: Thermosensitive nanofibers loaded with ciprofloxacin as antibacterial wound dressing materials
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: Ciprofloxacin, Electrospinning, P(LLA-CL), PDEGMA, Thermosensitive, Wound dressing
note: Copyright © 2016 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
abstract: To obtain wound dressings which could be removed easily without secondary injuries, we prepared thermoresponsive electrospun fiber mats containing poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA). Blend fibers of PDEGMA and poly(l-lactic acid-co-ε-caprolactone) (P(LLA-CL) were fabricated via electrospinning, and analogous fibers containing the antibiotic ciprofloxacin (CIF) were also prepared. Smooth cylindrical fibers were obtained, albeit with a small amount of beading visible for the ciprofloxacin-loaded fibers. X-ray diffraction showed the drug to exist in the amorphous physical form post-electrospinning. The composite fibers showed distinct thermosensitive properties and gave sustained release of CIF over more than 160h in vitro. The fibers could promote the proliferation of fibroblasts, and by varying the temperature cells could easily be attached to and detached from the fibers. Antibacterial tests demonstrated that fibers loaded with ciprofloxacin were effective in inhibiting the growth of E. coli and S. aureus. In vivo investigations on rats indicated that the composite PDEGMA/P(LLA-CL) fibers loaded with CIF had much more potent wound healing properties than a commercial gauze and CIF-loaded fibers made solely of P(LLA-CL). These results demonstrate the potential of PDEGMA/P(LLA-CL)/ciprofloxacin fibers as advanced wound dressing materials.
date: 2017-01-30
date_type: published
official_url: http://dx.doi.org/10.1016/j.ijpharm.2016.12.008
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1196117
doi: 10.1016/j.ijpharm.2016.12.008
pii: S0378-5173(16)31139-5
lyricists_name: Williams, Gareth
lyricists_id: GWILL02
actors_name: Williams, Gareth
actors_id: GWILL02
actors_role: owner
full_text_status: public
publication: International Journal of Pharmaceutics
volume: 517
number: 1-2
pagerange: 135-147
event_location: Netherlands
issn: 1873-3476
citation:        Li, H;    Williams, GR;    Wu, J;    Lv, Y;    Sun, X;    Wu, H;    Zhu, LM;      (2017)    Thermosensitive nanofibers loaded with ciprofloxacin as antibacterial wound dressing materials.                   International Journal of Pharmaceutics , 517  (1-2)   pp. 135-147.    10.1016/j.ijpharm.2016.12.008 <https://doi.org/10.1016/j.ijpharm.2016.12.008>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1532670/1/Li_Thermosensitive%20nanofibers%20loaded%20with%20ciprofloxacin%20as%20antibacterial%20wound%20dressing%20materials%20AAM.pdf