eprintid: 1530632
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/01/53/06/32
datestamp: 2016-12-04 01:09:50
lastmod: 2021-12-13 03:07:42
status_changed: 2016-12-14 18:26:49
type: article
metadata_visibility: show
creators_name: Kerai, LV
creators_name: Hilton, S
creators_name: Maugueret, M
creators_name: Kazi, BB
creators_name: Faull, J
creators_name: Bhakta, S
creators_name: Murdan, S
title: UV-curable gels as topical nail medicines:In vivo residence, anti-fungal efficacy and influence of gel components on their properties.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G09
divisions: G08
divisions: D13
divisions: G24
keywords: Acrylate, Amorolfine, Anti-fungal efficacy, In vivo, Onychomycosis, Permeation, Release, Residence, TOWL, Terbinafine, UV gel, Ungual
note: Copyright © 2016 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
abstract: UV-curable gels, used as nail cosmetics for their in vivo durability, were reported to be promising as topical nail medicines. Our first aim was thus to investigate whether such durability applies to drug-loaded formulations. This was found to be true. However, ethanol inclusion in the pharmaceutical formulation (to enable drug loading) reduced the in vivo residence. The second aim was therefore to determine any other effects of ethanol, and if ethanol could be avoided by the choice of monomers. Thus, three methacrylate monomers, ethyl methacrylate, isobornyl methacrylate and 2-hydroxyethyl methacrylate (HEMA) were selected, and their influence on the formulation properties were determined. Ethanol and the methacrylate monomer influenced some (but not all) of the formulation properties. The most significant was that HEMA could dissolve drug and enable the preparation of ethanol-free, drug-loaded formulations, which would benefit in vivo residence. The absence of ethanol reduced drug loading, release and ungual flux, but had no negative impact on the in vitro anti-fungal efficacy. Thus, judicious selection of gel components enabled the exclusion of ethanol. The long in vivo residence, little residual monomers, sufficient ungual permeation and in vitro anti-fungal activity of the gels indicates their potential as anti-onychomycotic topical medicines.
date: 2016-11-30
date_type: published
official_url: http://dx.doi.org/10.1016/j.ijpharm.2016.08.025
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1194558
doi: 10.1016/j.ijpharm.2016.08.025
pii: S0378-5173(16)30765-7
lyricists_name: Bhakta, Sanjib
lyricists_name: Hilton, Stephen
lyricists_name: Murdan, Sudaxshina
lyricists_id: SBHAK15
lyricists_id: SHILT85
lyricists_id: SMURD86
full_text_status: public
publication: International Journal of Pharmaceutics
volume: 514
number: 1
pagerange: 244-254
event_location: Netherlands
issn: 1873-3476
citation:        Kerai, LV;    Hilton, S;    Maugueret, M;    Kazi, BB;    Faull, J;    Bhakta, S;    Murdan, S;      (2016)    UV-curable gels as topical nail medicines:In vivo residence, anti-fungal efficacy and influence of gel components on their properties.                   International Journal of Pharmaceutics , 514  (1)   pp. 244-254.    10.1016/j.ijpharm.2016.08.025 <https://doi.org/10.1016/j.ijpharm.2016.08.025>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1530632/1/Kerai_UV-curable%20gels%20as%20topical%20nail%20medicines.pdf