eprintid: 1530632 rev_number: 28 eprint_status: archive userid: 608 dir: disk0/01/53/06/32 datestamp: 2016-12-04 01:09:50 lastmod: 2021-12-13 03:07:42 status_changed: 2016-12-14 18:26:49 type: article metadata_visibility: show creators_name: Kerai, LV creators_name: Hilton, S creators_name: Maugueret, M creators_name: Kazi, BB creators_name: Faull, J creators_name: Bhakta, S creators_name: Murdan, S title: UV-curable gels as topical nail medicines:In vivo residence, anti-fungal efficacy and influence of gel components on their properties. ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D10 divisions: G09 divisions: G08 divisions: D13 divisions: G24 keywords: Acrylate, Amorolfine, Anti-fungal efficacy, In vivo, Onychomycosis, Permeation, Release, Residence, TOWL, Terbinafine, UV gel, Ungual note: Copyright © 2016 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ abstract: UV-curable gels, used as nail cosmetics for their in vivo durability, were reported to be promising as topical nail medicines. Our first aim was thus to investigate whether such durability applies to drug-loaded formulations. This was found to be true. However, ethanol inclusion in the pharmaceutical formulation (to enable drug loading) reduced the in vivo residence. The second aim was therefore to determine any other effects of ethanol, and if ethanol could be avoided by the choice of monomers. Thus, three methacrylate monomers, ethyl methacrylate, isobornyl methacrylate and 2-hydroxyethyl methacrylate (HEMA) were selected, and their influence on the formulation properties were determined. Ethanol and the methacrylate monomer influenced some (but not all) of the formulation properties. The most significant was that HEMA could dissolve drug and enable the preparation of ethanol-free, drug-loaded formulations, which would benefit in vivo residence. The absence of ethanol reduced drug loading, release and ungual flux, but had no negative impact on the in vitro anti-fungal efficacy. Thus, judicious selection of gel components enabled the exclusion of ethanol. The long in vivo residence, little residual monomers, sufficient ungual permeation and in vitro anti-fungal activity of the gels indicates their potential as anti-onychomycotic topical medicines. date: 2016-11-30 date_type: published official_url: http://dx.doi.org/10.1016/j.ijpharm.2016.08.025 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1194558 doi: 10.1016/j.ijpharm.2016.08.025 pii: S0378-5173(16)30765-7 lyricists_name: Bhakta, Sanjib lyricists_name: Hilton, Stephen lyricists_name: Murdan, Sudaxshina lyricists_id: SBHAK15 lyricists_id: SHILT85 lyricists_id: SMURD86 full_text_status: public publication: International Journal of Pharmaceutics volume: 514 number: 1 pagerange: 244-254 event_location: Netherlands issn: 1873-3476 citation: Kerai, LV; Hilton, S; Maugueret, M; Kazi, BB; Faull, J; Bhakta, S; Murdan, S; (2016) UV-curable gels as topical nail medicines:In vivo residence, anti-fungal efficacy and influence of gel components on their properties. International Journal of Pharmaceutics , 514 (1) pp. 244-254. 10.1016/j.ijpharm.2016.08.025 <https://doi.org/10.1016/j.ijpharm.2016.08.025>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1530632/1/Kerai_UV-curable%20gels%20as%20topical%20nail%20medicines.pdf