%T Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes
%S Methods in Pharmacology and Toxicology
%V MIPT
%A J Kriston-Vizi
%A SE Harding
%A G Földes
%C New York, NY, USA
%I Humana Press
%P 271-291
%N 14
%L discovery1530159
%K Human pluripotent stem cells, Cardiomyocyte, Hypertrophy Automated high-content imaging
%O This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
%D 2017
%X Human pluripotent stem cells (hPSC) are investigated as a source of authentic human cardiac cells for drug discovery and toxicological tests. Cell-based assays performed using an automated fluorescence imaging platform and high-content analysis are valuable in characterizing hypertrophic states that may be induced in hPSC-derived cardiomyocytes upon exposure to cardiotoxic compounds. In high-purity populations of hPSC-derived cardiomyocytes loaded with cell tracer probes and other cell markers, detailed hypertrophic profiles can be assessed based on information captured at cellular and subcellular levels.
%E M Clements
%E L Roquemore
%B Stem Cell-Derived Models in Toxicology