%0 Book Section %A Kriston-Vizi, J %A Harding, SE %A Földes, G %B Stem Cell-Derived Models in Toxicology %C New York, NY, USA %D 2017 %E Clements, M %E Roquemore, L %F discovery:1530159 %I Humana Press %K Human pluripotent stem cells, Cardiomyocyte, Hypertrophy Automated high-content imaging %N 14 %P 271-291 %S Methods in Pharmacology and Toxicology %T Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes %U https://discovery.ucl.ac.uk/id/eprint/1530159/ %V MIPT %X Human pluripotent stem cells (hPSC) are investigated as a source of authentic human cardiac cells for drug discovery and toxicological tests. Cell-based assays performed using an automated fluorescence imaging platform and high-content analysis are valuable in characterizing hypertrophic states that may be induced in hPSC-derived cardiomyocytes upon exposure to cardiotoxic compounds. In high-purity populations of hPSC-derived cardiomyocytes loaded with cell tracer probes and other cell markers, detailed hypertrophic profiles can be assessed based on information captured at cellular and subcellular levels. %Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.