%0 Book Section
%A Kriston-Vizi, J
%A Harding, SE
%A Földes, G
%B Stem Cell-Derived Models in Toxicology
%C New York, NY, USA
%D 2017
%E Clements, M
%E Roquemore, L
%F discovery:1530159
%I Humana Press
%K Human pluripotent stem cells, Cardiomyocyte, Hypertrophy Automated high-content imaging
%N 14
%P 271-291
%S Methods in Pharmacology and Toxicology
%T Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes
%U https://discovery.ucl.ac.uk/id/eprint/1530159/
%V MIPT
%X Human pluripotent stem cells (hPSC) are investigated as a source of authentic human cardiac cells for drug discovery and toxicological tests. Cell-based assays performed using an automated fluorescence imaging platform and high-content analysis are valuable in characterizing hypertrophic states that may be induced in hPSC-derived cardiomyocytes upon exposure to cardiotoxic compounds. In high-purity populations of hPSC-derived cardiomyocytes loaded with cell tracer probes and other cell markers, detailed hypertrophic profiles can be assessed based on information captured at cellular and subcellular levels.
%Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.