%0 Journal Article
%@ 1546-1718
%A Barban, N
%A Jansen, R
%A de Vlaming, R
%A Vaez, A
%A Mandemakers, JJ
%A Tropf, FC
%A Shen, X
%A Wilson, JF
%A Chasman, DI
%A Nolte, IM
%A Tragante, V
%A van der Laan, SW
%A Perry, JRB
%A Kong, A
%A Ahluwalia, TS
%A Albrecht, E
%A Yerges-Armstrong, L
%A Atzmon, G
%A Auro, K
%A Ayers, K
%A Bakshi, A
%A Ben-Avraham, D
%A Berger, K
%A Bergman, A
%A Bertram, L
%A Bielak, LF
%A Bjornsdottir, G
%A Bonder, MJ
%A Broer, L
%A Bui, M
%A Barbieri, C
%A Cavadino, A
%A Chavarro, JE
%A Turman, C
%A Concas, MP
%A Cordell, HJ
%A Davies, G
%A Eibich, P
%A Eriksson, N
%A Esko, T
%A Eriksson, J
%A Falahi, F
%A Felix, JF
%A Fontana, MA
%A Franke, L
%A Gandin, I
%A Gaskins, AJ
%A Gieger, C
%A Gunderson, EP
%A Guo, X
%A Hayward, C
%A He, C
%A Hofer, E
%A Huang, H
%A Joshi, PK
%A Kanoni, S
%A Karlsson, R
%A Kiechl, S
%A Kifley, A
%A Kluttig, A
%A Kraft, P
%A Lagou, V
%A Lecoeur, C
%A Lahti, J
%A Li-Gao, R
%A Lind, PA
%A Liu, T
%A Makalic, E
%A Mamasoula, C
%A Matteson, L
%A Mbarek, H
%A McArdle, PF
%A McMahon, G
%A Meddens, SFW
%A Mihailov, E
%A Miller, M
%A Missmer, SA
%A Monnereau, C
%A van der Most, PJ
%A Myhre, R
%A Nalls, MA
%A Nutile, T
%A Kalafati, IP
%A Porcu, E
%A Prokopenko, I
%A Rajan, KB
%A Rich-Edwards, J
%A Rietveld, CA
%A Robino, A
%A Rose, LM
%A Rueedi, R
%A Ryan, K-A
%A Saba, Y
%A Schmidt, D
%A Smith, JA
%A Stolk, L
%A Streeten, E
%A Toenjes, A
%A Thorleifsson, G
%A Ulivi, S
%A Wedenoja, J
%A Wellmann, J
%A Willeit, P
%A Yao, J
%A Yengo, L
%A Zhao, JH
%A Zhao, W
%A Zhernakova, DV
%A Amin, N
%A Andrews, H
%A Balkau, B
%A Barzilai, N
%A Bergmann, S
%A Biino, G
%A Bisgaard, H
%A Bonnelykke, K
%A Boomsma, DI
%A Buring, JE
%A Campbell, H
%A Cappellani, S
%A Ciullo, M
%A Cox, SR
%A Cucca, F
%A Toniolo, D
%A Davey-Smith, G
%A Deary, IJ
%A Dedoussis, G
%A Deloukas, P
%A van Duijn, CM
%A de Geus, EJC
%A Eriksson, JG
%A Evans, DA
%A Faul, JD
%A Sala, CF
%A Froguel, P
%A Gasparini, P
%A Girotto, G
%A Grabe, H-J
%A Greiser, KH
%A Groenen, PJF
%A de Haan, HG
%A Haerting, J
%A Harris, TB
%A Heath, AC
%A Heikkila, K
%A Hofman, A
%A Homuth, G
%A Holliday, EG
%A Hopper, J
%A Hypponen, E
%A Jacobsson, B
%A Jaddoe', VWV
%A Johannesson, M
%A Kahonen, M
%A Kajantie, E
%A Kardia, SLR
%A Keavney, B
%A Kolcic, I
%A Koponen, P
%A Kovacs, P
%A Kronenberg, F
%A Kutalik, Z
%A La Bianca, M
%A Lachance, G
%A Iacono, WG
%A Lai, S
%A Lehtimaki, T
%A Liewald, DC
%A Lindgren, CM
%A Liu, Y
%A Luben, R
%A Lucht, M
%A Luoto, R
%A Magnus, P
%A Magnusson, PKE
%A Martin, NG
%A McGue, M
%A McQuillan, R
%A Medland, SE
%A Meisinger, C
%A Mellstrom, D
%A Metspalu, A
%A Traglia, M
%A Milani, L
%A Mitchell, P
%A Montgomery, GW
%A Mook-Kanamori, D
%A de Mutsert, R
%A Nohr, EA
%A Ohlsson, C
%A Olsen, P
%A Ong, KK
%A Paternoster, L
%A Pattie, A
%A Penninx, BWJH
%A Perola, M
%A Peyser, PA
%A Pirastu, M
%A Polasek, O
%A Power, C
%A Kaprio, J
%A Raffel, LJ
%A Raikkonen, K
%A Raitakari, O
%A Ridker, PM
%A Ring, SM
%A Roll, K
%A Rudan, I
%A Ruggiero, D
%A Rujescu, D
%A Salomaa, V
%A Schlessinger, D
%A Schmidt, H
%A Schmidt, R
%A Schupf, N
%A Smit, J
%A Sorice, R
%A Spector, TD
%A Starr, JM
%A Stockl, D
%A Strauch, K
%A Stumvoll, M
%A Swertz, MA
%A Thorsteinsdottir, U
%A Thurik, AR
%A Timpson, NJ
%A Tung, JY
%A Uitterlinden, AG
%A Vaccargiu, S
%A Viikari, J
%A Vitart, V
%A Voelzke, H
%A Vollenweider, P
%A Vuckovic, D
%A Waage, J
%A Wagner, GG
%A Wang, JJ
%A Wareham, NJ
%A Weir, DR
%A Willemsen, G
%A Willeit, J
%A Wright, AF
%A Zondervan, KT
%A Stefansson, K
%A Krueger, RF
%A Lee, JJ
%A Benjamin, DJ
%A Cesarini, D
%A Koellinger, PD
%A den Hoed, M
%A Snieder, H
%A Mills, MC
%D 2016
%F discovery:1527670
%I NATURE PUBLISHING GROUP
%J Nature Genetics
%N 12
%P 1462-1472
%T Genome-wide analysis identifies 12 loci influencing human reproductive behavior
%U https://discovery.ucl.ac.uk/id/eprint/1527670/
%V 48
%X The genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has  a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few  genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large  genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified  12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and  4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting  non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
%Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.