@article{discovery1527670,
       publisher = {NATURE PUBLISHING GROUP},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
           pages = {1462--1472},
         journal = {Nature Genetics},
           month = {December},
          number = {12},
           title = {Genome-wide analysis identifies 12 loci influencing human reproductive behavior},
            year = {2016},
          volume = {48},
        abstract = {The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has
a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few
genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large
genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified
12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and
4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting
non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.},
          author = {Barban, N and Jansen, R and de Vlaming, R and Vaez, A and Mandemakers, JJ and Tropf, FC and Shen, X and Wilson, JF and Chasman, DI and Nolte, IM and Tragante, V and van der Laan, SW and Perry, JRB and Kong, A and Ahluwalia, TS and Albrecht, E and Yerges-Armstrong, L and Atzmon, G and Auro, K and Ayers, K and Bakshi, A and Ben-Avraham, D and Berger, K and Bergman, A and Bertram, L and Bielak, LF and Bjornsdottir, G and Bonder, MJ and Broer, L and Bui, M and Barbieri, C and Cavadino, A and Chavarro, JE and Turman, C and Concas, MP and Cordell, HJ and Davies, G and Eibich, P and Eriksson, N and Esko, T and Eriksson, J and Falahi, F and Felix, JF and Fontana, MA and Franke, L and Gandin, I and Gaskins, AJ and Gieger, C and Gunderson, EP and Guo, X and Hayward, C and He, C and Hofer, E and Huang, H and Joshi, PK and Kanoni, S and Karlsson, R and Kiechl, S and Kifley, A and Kluttig, A and Kraft, P and Lagou, V and Lecoeur, C and Lahti, J and Li-Gao, R and Lind, PA and Liu, T and Makalic, E and Mamasoula, C and Matteson, L and Mbarek, H and McArdle, PF and McMahon, G and Meddens, SFW and Mihailov, E and Miller, M and Missmer, SA and Monnereau, C and van der Most, PJ and Myhre, R and Nalls, MA and Nutile, T and Kalafati, IP and Porcu, E and Prokopenko, I and Rajan, KB and Rich-Edwards, J and Rietveld, CA and Robino, A and Rose, LM and Rueedi, R and Ryan, K-A and Saba, Y and Schmidt, D and Smith, JA and Stolk, L and Streeten, E and Toenjes, A and Thorleifsson, G and Ulivi, S and Wedenoja, J and Wellmann, J and Willeit, P and Yao, J and Yengo, L and Zhao, JH and Zhao, W and Zhernakova, DV and Amin, N and Andrews, H and Balkau, B and Barzilai, N and Bergmann, S and Biino, G and Bisgaard, H and Bonnelykke, K and Boomsma, DI and Buring, JE and Campbell, H and Cappellani, S and Ciullo, M and Cox, SR and Cucca, F and Toniolo, D and Davey-Smith, G and Deary, IJ and Dedoussis, G and Deloukas, P and van Duijn, CM and de Geus, EJC and Eriksson, JG and Evans, DA and Faul, JD and Sala, CF and Froguel, P and Gasparini, P and Girotto, G and Grabe, H-J and Greiser, KH and Groenen, PJF and de Haan, HG and Haerting, J and Harris, TB and Heath, AC and Heikkila, K and Hofman, A and Homuth, G and Holliday, EG and Hopper, J and Hypponen, E and Jacobsson, B and Jaddoe', VWV and Johannesson, M and Kahonen, M and Kajantie, E and Kardia, SLR and Keavney, B and Kolcic, I and Koponen, P and Kovacs, P and Kronenberg, F and Kutalik, Z and La Bianca, M and Lachance, G and Iacono, WG and Lai, S and Lehtimaki, T and Liewald, DC and Lindgren, CM and Liu, Y and Luben, R and Lucht, M and Luoto, R and Magnus, P and Magnusson, PKE and Martin, NG and McGue, M and McQuillan, R and Medland, SE and Meisinger, C and Mellstrom, D and Metspalu, A and Traglia, M and Milani, L and Mitchell, P and Montgomery, GW and Mook-Kanamori, D and de Mutsert, R and Nohr, EA and Ohlsson, C and Olsen, P and Ong, KK and Paternoster, L and Pattie, A and Penninx, BWJH and Perola, M and Peyser, PA and Pirastu, M and Polasek, O and Power, C and Kaprio, J and Raffel, LJ and Raikkonen, K and Raitakari, O and Ridker, PM and Ring, SM and Roll, K and Rudan, I and Ruggiero, D and Rujescu, D and Salomaa, V and Schlessinger, D and Schmidt, H and Schmidt, R and Schupf, N and Smit, J and Sorice, R and Spector, TD and Starr, JM and Stockl, D and Strauch, K and Stumvoll, M and Swertz, MA and Thorsteinsdottir, U and Thurik, AR and Timpson, NJ and Tung, JY and Uitterlinden, AG and Vaccargiu, S and Viikari, J and Vitart, V and Voelzke, H and Vollenweider, P and Vuckovic, D and Waage, J and Wagner, GG and Wang, JJ and Wareham, NJ and Weir, DR and Willemsen, G and Willeit, J and Wright, AF and Zondervan, KT and Stefansson, K and Krueger, RF and Lee, JJ and Benjamin, DJ and Cesarini, D and Koellinger, PD and den Hoed, M and Snieder, H and Mills, MC},
             url = {http://doi.org/10.1038/ng.3698},
            issn = {1546-1718}
}