eprintid: 1520912
rev_number: 29
eprint_status: archive
userid: 608
dir: disk0/01/52/09/12
datestamp: 2016-10-12 11:05:19
lastmod: 2022-01-24 01:54:18
status_changed: 2016-10-12 11:05:19
type: article
metadata_visibility: show
creators_name: The European Paediatric HIVHCV Co-infection Study Group in the E, 
title: Co-infection with HIV and HCV in 229 children and young adults living in Europe
ispublished: pub
divisions: UCL
divisions: B02
divisions: D65
divisions: J38
divisions: D13
divisions: G25
keywords: coinfection, hepatitis C, HIV, paediatric, vertical infection
note: This is a non-final version of an article published in final form in: Thorne, C; Turkova, A; Indolfi, G; Venturini, E; Giaquinto, C; (2016) Co-infection with HIV and HCV in 229 children and young adults living in Europe. AIDS. http://dx.doi.org/10.1097/QAD.0000000000001285.
abstract: OBJECTIVE: To characterise children, adolescents and young adults infected with HIV/HCV vertically or before age 18 years and living in Europe regarding mode of acquisition, HCV genotype, clinical status and treatment. DESIGN: Retrospective, cross-sectional study using pooled data from 11 European paediatric HIV cohorts METHODS:: Patients aged > 18 months and < 25 years, with HIV/HCV acquired vertically or in childhood, were included. Anonymised individual-patient data were collected using a standard protocol and modified HIV Cohorts Data Exchange Protocol. RESULTS: Of 229 patients included, 142 (62%) had vertically-acquired infection. Median age at last follow-up was 16.2 years. Most children had HCV genotype 1 (101/184, 55%) or 3 (57/184, 31%). One-fifth (46/214) had a previous AIDS diagnosis (data missing on prior AIDS diagnoses for 15). At their last clinic visit, 70% (145/208) had no/mild immunosuppression (CDC stage 1) and 131 of 179 on antiretroviral therapy (ART) had undetectable HIV RNA (assay thresholds varied from < 20 to < 150 copies/ml). Overall 42% (86/204) had hepatomegaly in the previous year and 55% (116/213) had ALT > 40 IU/L at their last test. Of 97 patients with transient elastography, 12 had results > 9 kPa; this was associated with duration of HCV infection (p = 0.033), but not with CD4 count, ART use or gender in univariable analysis. Of 17 subjects with liver biopsies, 6 had bridging fibrosis and one cirrhosis. Twenty-five (11%) had been treated successfully for HCV. CONCLUSIONS: The high proportion of patients with progressive liver disease underscores the need for close monitoring and earlier and more effective HCV treatment.
date: 2017-01-02
date_type: published
official_url: http://dx.doi.org/10.1097/QAD.0000000000001285
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1181758
doi: 10.1097/QAD.0000000000001285
lyricists_name: Judd, Ali
lyricists_name: Thorne, Claire
lyricists_id: AJUDD59
lyricists_id: CNTHO93
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: AIDS
volume: 31
number: 1
pagerange: 127-135
issn: 1473-5571
citation:        The European Paediatric HIVHCV Co-infection Study Group in the E;      (2017)    Co-infection with HIV and HCV in 229 children and young adults living in Europe.                   AIDS , 31  (1)   pp. 127-135.    10.1097/QAD.0000000000001285 <https://doi.org/10.1097/QAD.0000000000001285>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1520912/1/00002030-900000000-97666.pdf