eprintid: 1519888 rev_number: 33 eprint_status: archive userid: 608 dir: disk0/01/51/98/88 datestamp: 2016-10-08 19:36:10 lastmod: 2021-09-17 22:04:17 status_changed: 2017-01-12 14:48:03 type: article metadata_visibility: show creators_name: Bunday, KL creators_name: Lemon, RN creators_name: Kilner, JM creators_name: Davare, M creators_name: Orban, GA title: Grasp-specific motor resonance is influenced by the visibility of the observed actor ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F84 divisions: F85 keywords: Science & Technology, Life Sciences & Biomedicine, Behavioral Sciences, Neurosciences, Neurosciences & Neurology, Action observation, Motor resonance, MEPs, Videos, F5c, TRANSCRANIAL MAGNETIC STIMULATION, VENTRAL PREMOTOR CORTEX, OBJECT-DRIVEN GRASP, CORTICOSPINAL EXCITABILITY, MIRROR NEURONS, HAND ACTIONS, SURROUND INHIBITION, MACAQUE MONKEY, FACILITATION, HUMANS note: © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). abstract: Motor resonance is the modulation of M1 corticospinal excitability induced by observation of others' actions. Recent brain imaging studies have revealed that viewing videos of grasping actions led to a differential activation of the ventral premotor cortex depending on whether the entire person is viewed versus only their disembodied hand. Here we used transcranial magnetic stimulation (TMS) to examine motor evoked potentials (MEPs) in the first dorsal interosseous (FDI) and abductor digiti minimi (ADM) during observation of videos or static images in which a whole person or merely the hand was seen reaching and grasping a peanut (precision grip) or an apple (whole hand grasp). Participants were presented with six visual conditions in which visual stimuli (video vs static image), view (whole person vs hand) and grasp (precision grip vs whole hand grasp) were varied in a 2 × 2 × 2 factorial design. Observing videos, but not static images, of a hand grasping different objects resulted in a grasp-specific interaction, such that FDI and ADM MEPs were differentially modulated depending on the type of grasp being observed (precision grip vs whole hand grasp). This interaction was present when observing the hand acting, but not when observing the whole person acting. Additional experiments revealed that these results were unlikely to be due to the relative size of the hand being observed. Our results suggest that observation of videos rather than static images is critical for motor resonance. Importantly, observing the whole person performing the action abolished the grasp-specific effect, which could be due to a variety of PMv inputs converging on M1. date: 2016-11-01 date_type: published publisher: ELSEVIER MASSON official_url: http://dx.doi.org/10.1016/j.cortex.2016.09.002 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Article verified: verified_manual elements_id: 1181689 doi: 10.1016/j.cortex.2016.09.002 language_elements: English lyricists_name: Bunday, Karen lyricists_name: Davare, Marco lyricists_name: Kilner, James lyricists_name: Lemon, Roger lyricists_id: KBUND89 lyricists_id: MDAVA99 lyricists_id: JMKIL68 lyricists_id: RNLEM52 actors_name: Barczynska, Patrycja actors_id: PBARC91 actors_role: owner full_text_status: public publication: Cortex volume: 84 pagerange: 43-54 pages: 12 issn: 0010-9452 citation: Bunday, KL; Lemon, RN; Kilner, JM; Davare, M; Orban, GA; (2016) Grasp-specific motor resonance is influenced by the visibility of the observed actor. Cortex , 84 pp. 43-54. 10.1016/j.cortex.2016.09.002 <https://doi.org/10.1016/j.cortex.2016.09.002>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1519888/1/1-s2.0-S0010945216302349-main.pdf