eprintid: 1518093
rev_number: 35
eprint_status: archive
userid: 608
dir: disk0/01/51/80/93
datestamp: 2016-10-01 19:26:16
lastmod: 2021-12-20 00:46:43
status_changed: 2017-09-07 13:18:09
type: article
metadata_visibility: show
creators_name: Di Nardo, G
creators_name: Di Lorenzo, C
creators_name: Lauro, A
creators_name: Stanghellini, V
creators_name: Thapar, N
creators_name: Karunaratne, TB
creators_name: Volta, U
creators_name: De Giorgio, R
title: Chronic intestinal pseudo-obstruction in children and adults: diagnosis and therapeutic options
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G22
keywords: chronic intestinal pseudo-obstruction, clinical manifestations, histopathology, manometry, nutritional therapy
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: BACKGROUND: Chronic intestinal pseudo-obstruction (CIPO) represents the most severe form of gastrointestinal dysmotility with debilitating and potentially lethal consequences. Symptoms can be non-specific, and result in this condition being diagnosed incorrectly or too late with consequences for morbidity and even mortality. PURPOSE: The present article aims to provide pediatric and adult gastroenterologists with an up to date review about clinical features, diagnosis and therapeutic options for CIPO. Although pediatric and adult CIPO share many clinical aspects distinctive features can be identified. There is no single diagnostic test or pathognomonic finding of CIPO, thus a stepwise approach including radiology, endoscopy, laboratory, manometry, and histopathology should be considered in the diagnostic work-up. Treatment of patients with CIPO is challenging and requires a multidisciplinary effort with participation of appropriately experienced gastroenterologists, pathologists, dieticians, surgeons, psychologists, and other subspecialists based on the presence of comorbidities. Current treatment options invariably involve surgery and specialized nutritional support, especially in children. Medical therapies are mainly aimed to avoid complications such as sepsis or intestinal bacterial overgrowth and, where possible, restore intestinal propulsion. More efficacious therapeutic options are eagerly awaited for such difficult patients.
date: 2017-01
date_type: published
official_url: http://dx.doi.org/10.1111/nmo.12945
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1180821
doi: 10.1111/nmo.12945
lyricists_name: Thapar, Nikhil
lyricists_id: NTHAP68
actors_name: Allington-Smith, Dominic
actors_id: DAALL44
actors_role: owner
full_text_status: public
publication: Neurogastroenterology & Motility
volume: 29
number: 1
article_number: e12945
event_location: England
issn: 1365-2982
citation:        Di Nardo, G;    Di Lorenzo, C;    Lauro, A;    Stanghellini, V;    Thapar, N;    Karunaratne, TB;    Volta, U;           Di Nardo, G;  Di Lorenzo, C;  Lauro, A;  Stanghellini, V;  Thapar, N;  Karunaratne, TB;  Volta, U;  De Giorgio, R;   - view fewer <#>    (2017)    Chronic intestinal pseudo-obstruction in children and adults: diagnosis and therapeutic options.                   Neurogastroenterology & Motility , 29  (1)    , Article e12945.  10.1111/nmo.12945 <https://doi.org/10.1111/nmo.12945>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1518093/1/Thapar_Review%20CIPO%20ChildrenAdults-NMO-Resubmission-Final.pdf