TY - JOUR N1 - Copyright © 2016 Nature America, Inc. All rights reserved. UR - http://dx.doi.org/10.1038/ng.3654 ID - discovery1516363 PB - NATURE PUBLISHING GROUP JF - Nature Genetics SP - 1151 N2 - High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ~155,063 samples for independent replication. We identified 30 new blood pressure? or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention. SN - 1061-4036 AV - public TI - Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension Y1 - 2016/10// VL - 48 EP - 1161 KW - Science & Technology KW - Life Sciences & Biomedicine KW - Genetics & Heredity KW - Genome-wide Association KW - Gene-centric Array KW - Cardiovascular-disease KW - Aging Research KW - Plasma-levels KW - Risk-factors KW - Loci KW - Charge KW - Heart KW - Identification A1 - Surendran, P A1 - Drenos, F A1 - Young, R A1 - Warren, H A1 - Cook, JP A1 - Manning, AK A1 - Grarup, N A1 - Sim, X A1 - Barnes, DR A1 - Witkowska, K A1 - Staley, JR A1 - Tragante, V A1 - Tukiainen, T A1 - Yaghootkar, H A1 - Masca, N A1 - Freitag, DF A1 - Ferreira, T A1 - Giannakopoulou, O A1 - Tinker, A A1 - Harakalova, M A1 - Mihailov, E A1 - Liu, C A1 - Kraja, AT A1 - Nielsen, SF A1 - Rasheed, A A1 - Samue, M A1 - Zhao, W A1 - Bonnycastle, LL A1 - Jackson, AU A1 - Narisu, N A1 - Swift, AJ A1 - Southam, L A1 - Marten, J A1 - Huyghe, JR A1 - Stancakova, A A1 - Fava, C A1 - Ohlsson, T A1 - Matchan, A A1 - Stirrups, KE A1 - Bork-Jensen, J A1 - Gjesing, AP A1 - Kontto, J A1 - Perola, M A1 - Shaw-Hawkins, S A1 - Havulinna, AS A1 - Zhang, H A1 - Donnelly, LA A1 - Groves, CJ A1 - Rayner, NW A1 - Neville, MJ A1 - Robertson, NR A1 - Yiorkas, AM A1 - Herzig, K-H A1 - Kajantie, E A1 - Zhang, W A1 - Willems, SM A1 - Lannfelt, L A1 - Malerba, G A1 - Soranzo, N A1 - Trabetti, E A1 - Verweij, N A1 - Evangelou, E A1 - Moayyeri, A A1 - Vergnaud, A-C A1 - Nelson, CP A1 - Poveda, A A1 - Varga, TV A1 - Caslake, M A1 - de Craen, AJM A1 - Trompet, S A1 - Luan, J A1 - Scott, RA A1 - Harris, SE A1 - Liewald, DCM A1 - Marioni, R A1 - Menni, C A1 - Farmaki, A-E A1 - Hallmans, G A1 - Renstrom, F A1 - Huffman, JE A1 - Hassinen, M A1 - Burgess, S A1 - Vasan, RS A1 - Felix, JF A1 - Uria-Nickelsen, M A1 - Malarstign, A A1 - Reilly, DF A1 - Hoek, M A1 - Vogt, TF A1 - Lin, H A1 - Lieb, W A1 - Traylor, M A1 - Markus, HS A1 - Highland, HM A1 - Justice, AE A1 - Marouli, E A1 - Lindstrom, J A1 - Uusitupa, M A1 - Komulainen, P A1 - Lakka, TA A1 - Rauramaa, R A1 - Polasek, O A1 - Rudan, I A1 - Rolandsson, O A1 - Franks, PW A1 - Dedoussis, G A1 - Spector, TD A1 - Jousilahti, P A1 - Mannisto, S A1 - Deary, IJ A1 - Starr, JM A1 - Langenberg, C A1 - Wareham, NJ A1 - Brown, MJ A1 - Dominiczak, AF A1 - Connell, JM A1 - Jukema, JW A1 - Sattar, N A1 - Ford, I A1 - Packard, CJ A1 - Esko, T A1 - Magi, R A1 - Metspalu, A A1 - de Boer, RA A1 - van der Meer, P A1 - van der Harst, P A1 - Gambaro, G A1 - Ingelsson, E A1 - Lind, L A1 - de Bakker, PIW A1 - Numans, ME A1 - Brandslund, I A1 - Christensen, C A1 - Petersen, ERB A1 - Korpi-Hyovalti, E A1 - Oksa, H A1 - Chambers, JC A1 - Kooner, JS A1 - Blakemore, AIF A1 - Franks, S A1 - Jarvelin, M-R A1 - Husemoen, LL A1 - Linneberg, A A1 - Skaaby, T A1 - Thuesen, B A1 - Karpe, F A1 - Tuomilehto, J A1 - Doney, ASF A1 - Morris, AD A1 - Palmer, CNA A1 - Holmen, OL A1 - Hveem, K A1 - Willer, CJ A1 - Tuomi, T A1 - Groop, L A1 - Karajamaki, A A1 - Palotie, A A1 - Ripatti, S A1 - Salomaa, V A1 - Alam, DS A1 - Majmnder, AAS A1 - Di Angelantonio, E A1 - Chowdhury, R A1 - McCarthy, MI A1 - Poulter, N A1 - Stanton, AV A1 - Sever, P A1 - Amouyel, P A1 - Arveiler, D A1 - Blankenberg, S A1 - Ferrieres, J A1 - Kee, F A1 - Kuulasmaa, K A1 - Muller-Nurasyid, M A1 - Veronesi, G A1 - Virtamo, J A1 - Deloukas, P A1 - Elliott, P A1 - Zeggini, E A1 - Kathiresan, S A1 - Melander, O A1 - Kuusisto, J A1 - Laakso, M A1 - Padmanabhan, S A1 - Porteous, DJ A1 - Hayward, C A1 - Scotland, G A1 - Collins, FS A1 - Mohlke, KL A1 - Hansen, T A1 - Pedersen, O A1 - Boehnke, M A1 - Stringham, HM A1 - Frossard, P A1 - Newton-Cheh, C A1 - Tobin, MD A1 - Nordestgaard, BG A1 - Caulfield, MJ A1 - Mahajan, A A1 - Morris, AP A1 - Tomaszewski, M A1 - Samani, NJ A1 - Saleheen, D A1 - Asselbergs, FW A1 - Lindgren, CM A1 - Danesh, J A1 - Wain, LV A1 - Butterworth, AS A1 - Howson, JMM A1 - Munroe, PB IS - 10 ER -