TY  - JOUR
N1  - Copyright © 2016 Nature America, Inc. All rights reserved.
UR  - http://dx.doi.org/10.1038/ng.3654
ID  - discovery1516363
PB  - NATURE PUBLISHING GROUP
JF  - Nature Genetics
SP  - 1151
N2  - High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ~155,063 samples for independent replication. We identified 30 new blood pressure? or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.
SN  - 1061-4036
AV  - public
TI  - Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Y1  - 2016/10//
VL  - 48
EP  - 1161
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Genetics & Heredity
KW  -  Genome-wide Association
KW  -  Gene-centric Array
KW  -  Cardiovascular-disease
KW  -  Aging Research
KW  -  Plasma-levels
KW  -  Risk-factors
KW  -  Loci
KW  -  Charge
KW  -  Heart
KW  -  Identification
A1  - Surendran, P
A1  - Drenos, F
A1  - Young, R
A1  - Warren, H
A1  - Cook, JP
A1  - Manning, AK
A1  - Grarup, N
A1  - Sim, X
A1  - Barnes, DR
A1  - Witkowska, K
A1  - Staley, JR
A1  - Tragante, V
A1  - Tukiainen, T
A1  - Yaghootkar, H
A1  - Masca, N
A1  - Freitag, DF
A1  - Ferreira, T
A1  - Giannakopoulou, O
A1  - Tinker, A
A1  - Harakalova, M
A1  - Mihailov, E
A1  - Liu, C
A1  - Kraja, AT
A1  - Nielsen, SF
A1  - Rasheed, A
A1  - Samue, M
A1  - Zhao, W
A1  - Bonnycastle, LL
A1  - Jackson, AU
A1  - Narisu, N
A1  - Swift, AJ
A1  - Southam, L
A1  - Marten, J
A1  - Huyghe, JR
A1  - Stancakova, A
A1  - Fava, C
A1  - Ohlsson, T
A1  - Matchan, A
A1  - Stirrups, KE
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A1  - Gjesing, AP
A1  - Kontto, J
A1  - Perola, M
A1  - Shaw-Hawkins, S
A1  - Havulinna, AS
A1  - Zhang, H
A1  - Donnelly, LA
A1  - Groves, CJ
A1  - Rayner, NW
A1  - Neville, MJ
A1  - Robertson, NR
A1  - Yiorkas, AM
A1  - Herzig, K-H
A1  - Kajantie, E
A1  - Zhang, W
A1  - Willems, SM
A1  - Lannfelt, L
A1  - Malerba, G
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A1  - Trabetti, E
A1  - Verweij, N
A1  - Evangelou, E
A1  - Moayyeri, A
A1  - Vergnaud, A-C
A1  - Nelson, CP
A1  - Poveda, A
A1  - Varga, TV
A1  - Caslake, M
A1  - de Craen, AJM
A1  - Trompet, S
A1  - Luan, J
A1  - Scott, RA
A1  - Harris, SE
A1  - Liewald, DCM
A1  - Marioni, R
A1  - Menni, C
A1  - Farmaki, A-E
A1  - Hallmans, G
A1  - Renstrom, F
A1  - Huffman, JE
A1  - Hassinen, M
A1  - Burgess, S
A1  - Vasan, RS
A1  - Felix, JF
A1  - Uria-Nickelsen, M
A1  - Malarstign, A
A1  - Reilly, DF
A1  - Hoek, M
A1  - Vogt, TF
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A1  - Lieb, W
A1  - Traylor, M
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A1  - Highland, HM
A1  - Justice, AE
A1  - Marouli, E
A1  - Lindstrom, J
A1  - Uusitupa, M
A1  - Komulainen, P
A1  - Lakka, TA
A1  - Rauramaa, R
A1  - Polasek, O
A1  - Rudan, I
A1  - Rolandsson, O
A1  - Franks, PW
A1  - Dedoussis, G
A1  - Spector, TD
A1  - Jousilahti, P
A1  - Mannisto, S
A1  - Deary, IJ
A1  - Starr, JM
A1  - Langenberg, C
A1  - Wareham, NJ
A1  - Brown, MJ
A1  - Dominiczak, AF
A1  - Connell, JM
A1  - Jukema, JW
A1  - Sattar, N
A1  - Ford, I
A1  - Packard, CJ
A1  - Esko, T
A1  - Magi, R
A1  - Metspalu, A
A1  - de Boer, RA
A1  - van der Meer, P
A1  - van der Harst, P
A1  - Gambaro, G
A1  - Ingelsson, E
A1  - Lind, L
A1  - de Bakker, PIW
A1  - Numans, ME
A1  - Brandslund, I
A1  - Christensen, C
A1  - Petersen, ERB
A1  - Korpi-Hyovalti, E
A1  - Oksa, H
A1  - Chambers, JC
A1  - Kooner, JS
A1  - Blakemore, AIF
A1  - Franks, S
A1  - Jarvelin, M-R
A1  - Husemoen, LL
A1  - Linneberg, A
A1  - Skaaby, T
A1  - Thuesen, B
A1  - Karpe, F
A1  - Tuomilehto, J
A1  - Doney, ASF
A1  - Morris, AD
A1  - Palmer, CNA
A1  - Holmen, OL
A1  - Hveem, K
A1  - Willer, CJ
A1  - Tuomi, T
A1  - Groop, L
A1  - Karajamaki, A
A1  - Palotie, A
A1  - Ripatti, S
A1  - Salomaa, V
A1  - Alam, DS
A1  - Majmnder, AAS
A1  - Di Angelantonio, E
A1  - Chowdhury, R
A1  - McCarthy, MI
A1  - Poulter, N
A1  - Stanton, AV
A1  - Sever, P
A1  - Amouyel, P
A1  - Arveiler, D
A1  - Blankenberg, S
A1  - Ferrieres, J
A1  - Kee, F
A1  - Kuulasmaa, K
A1  - Muller-Nurasyid, M
A1  - Veronesi, G
A1  - Virtamo, J
A1  - Deloukas, P
A1  - Elliott, P
A1  - Zeggini, E
A1  - Kathiresan, S
A1  - Melander, O
A1  - Kuusisto, J
A1  - Laakso, M
A1  - Padmanabhan, S
A1  - Porteous, DJ
A1  - Hayward, C
A1  - Scotland, G
A1  - Collins, FS
A1  - Mohlke, KL
A1  - Hansen, T
A1  - Pedersen, O
A1  - Boehnke, M
A1  - Stringham, HM
A1  - Frossard, P
A1  - Newton-Cheh, C
A1  - Tobin, MD
A1  - Nordestgaard, BG
A1  - Caulfield, MJ
A1  - Mahajan, A
A1  - Morris, AP
A1  - Tomaszewski, M
A1  - Samani, NJ
A1  - Saleheen, D
A1  - Asselbergs, FW
A1  - Lindgren, CM
A1  - Danesh, J
A1  - Wain, LV
A1  - Butterworth, AS
A1  - Howson, JMM
A1  - Munroe, PB
IS  - 10
ER  -