eprintid: 1514941 rev_number: 27 eprint_status: archive userid: 608 dir: disk0/01/51/49/41 datestamp: 2016-09-11 03:17:18 lastmod: 2021-09-29 22:40:42 status_changed: 2016-11-09 12:05:09 type: article metadata_visibility: show creators_name: Bartlett, RD creators_name: Choi, D creators_name: Phillips, JB title: Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F82 divisions: C08 divisions: D10 divisions: G10 keywords: Science & Technology, Life Sciences & Biomedicine, Technology, Cell & Tissue Engineering, Engineering, Biomedical, Cell Biology, Engineering, biomechanical properties, biomechanics, CNS, mechanical properties, regenerative medicine, spinal cord, spinal cord injury, spinal cord repair, tissue engineering, MAGNETIC-RESONANCE ELASTOGRAPHY, CENTRAL-NERVOUS-SYSTEM, TRAUMATIC BRAIN-INJURY, MECHANICAL-PROPERTIES, WHITE-MATTER, VISCOELASTIC PROPERTIES, IN-VIVO, BIOLOGICAL TISSUES, FORCE MICROSCOPY, MR ELASTOGRAPHY note: This is the peer reviewed version of the following article: James B. Phillips, Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation, Regenerative Medicine October 2016 ,Vol. 11, No. 7, Pages 659-673, which has been published in final form at: 10.2217/rme-2016-0065 abstract: Spinal cord injury is a severely debilitating condition which can leave individuals paralyzed and suffering from autonomic dysfunction. Regenerative medicine may offer a promising solution to this problem. Previous research has focused primarily on exploring the cellular and biological aspects of the spinal cord, yet relatively little remains known about the biomechanical properties of spinal cord tissue. Given that a number of regenerative strategies aim to deliver cells and materials in the form of tissue-engineered therapies, understanding the biomechanical properties of host spinal cord tissue is important. We review the relevant biomechanical properties of spinal cord tissue and provide the baseline knowledge required to apply these important physical concepts to spinal cord tissue engineering. date: 2016-10-01 date_type: published publisher: FUTURE MEDICINE LTD official_url: http://dx.doi.org/10.2217/rme-2016-0065 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Review verified: verified_manual elements_id: 1157704 doi: 10.2217/rme-2016-0065 language_elements: English lyricists_name: Choi, David lyricists_name: Phillips, James lyricists_id: DCHOI64 lyricists_id: JBPHI82 actors_name: Phillips, James actors_name: Barczynska, Patrycja actors_id: JBPHI82 actors_id: PBARC91 actors_role: owner actors_role: impersonator full_text_status: public publication: Regenrative Medicine volume: 11 number: 7 pagerange: 659-673 pages: 15 issn: 1746-0751 citation: Bartlett, RD; Choi, D; Phillips, JB; (2016) Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation. Regenrative Medicine , 11 (7) pp. 659-673. 10.2217/rme-2016-0065 <https://doi.org/10.2217/rme-2016-0065>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1514941/1/Bartlett%20complete%20formatted%20manuscript%20%28with%20figures%20at%20end%29.pdf