eprintid: 15090
rev_number: 73
eprint_status: archive
userid: 587
dir: disk0/00/01/50/90
datestamp: 2009-04-08 15:16:23
lastmod: 2021-12-13 01:48:58
status_changed: 2009-04-08 15:16:23
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Wells, JCK
creators_name: Fewtrell, MS
creators_name: Davies, PSW
creators_name: Williams, JE
creators_name: Coward, WA
creators_name: Cole, TJ
title: Prediction of total body water in infants and children
subjects: 25300
subjects: 22000
divisions: UCL
divisions: B02
divisions: D13
divisions: G25
keywords: PHYSICAL-ACTIVITY, REFERENCE CURVES, BREAST-MILK, MASS INDEX, FAT, ADOLESCENTS, UK, ZARAGOZA, FATNESS, OBESITY
abstract: Background: In paediatric clinical practice treatment is often adjusted in relation to body size, for example the calculation of pharmacological and dialysis dosages. In addition to use of body weight, for some purposes total body water (TBW) and surface area are estimated from anthropometry using equations developed several decades previously. Whether such equations remain valid in contemporary populations is not known.Methods: Total body water was measured using deuterium dilution in 672 subjects (265 infants aged < 1 year; 407 children and adolescents aged 1-19 years) during the period 1990-2003. TBW was predicted (a) using published equations, and (b) directly from data on age, sex, weight, and height.Results: Previously published equations, based on data obtained before 1970, significantly overestimated TBW, with average biases ranging from 4% to 11%. For all equations, the overestimation of TBW was greatest in infancy. New equations were generated. The best equation, incorporating log weight, log height, age, and sex, had a standard error of the estimate of 7.8%.Conclusions: Secular trends in the nutritional status of infants and children are altering the relation between age or weight and TBW. Equations developed in previous decades significantly overestimate TBW in all age groups, especially infancy; however, the relation between TBW and weight may continue to change. This scenario is predicted to apply more generally to many aspects of paediatric clinical practice in which dosages are calculated on the basis of anthropometric data collected in previous decades.
date: 2005-09
publisher: B M J PUBLISHING GROUP
official_url: http://www.ncbi.nlm.nih.gov/pmc/
articles/PMC1720559/?tool=pubmed
oa_status: green
pmcid: PMC1720559
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_batch
elements_source: Web of Science
elements_id: 69253
doi: 10.1136/adc.2004.067538
lyricists_name: Cole, Timothy
lyricists_name: Fewtrell, Mary
lyricists_name: Wells, Jonathan
lyricists_name: Williams, Jane
lyricists_id: TCOLE39
lyricists_id: MFEWT52
lyricists_id: JWELL04
lyricists_id: JWILL17
full_text_status: public
publication: ARCH DIS CHILD
volume: 90
number: 9
pagerange: 965 - 971
refereed: TRUE
issn: 0003-9888
citation:        Wells, JCK;    Fewtrell, MS;    Davies, PSW;    Williams, JE;    Coward, WA;    Cole, TJ;      (2005)    Prediction of total body water in infants and children.                   ARCH DIS CHILD , 90  (9)   965 - 971.    10.1136/adc.2004.067538 <https://doi.org/10.1136/adc.2004.067538>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/15090/1/15090.pdf