eprintid: 15090 rev_number: 73 eprint_status: archive userid: 587 dir: disk0/00/01/50/90 datestamp: 2009-04-08 15:16:23 lastmod: 2021-12-13 01:48:58 status_changed: 2009-04-08 15:16:23 type: article metadata_visibility: show item_issues_count: 0 creators_name: Wells, JCK creators_name: Fewtrell, MS creators_name: Davies, PSW creators_name: Williams, JE creators_name: Coward, WA creators_name: Cole, TJ title: Prediction of total body water in infants and children subjects: 25300 subjects: 22000 divisions: UCL divisions: B02 divisions: D13 divisions: G25 keywords: PHYSICAL-ACTIVITY, REFERENCE CURVES, BREAST-MILK, MASS INDEX, FAT, ADOLESCENTS, UK, ZARAGOZA, FATNESS, OBESITY abstract: Background: In paediatric clinical practice treatment is often adjusted in relation to body size, for example the calculation of pharmacological and dialysis dosages. In addition to use of body weight, for some purposes total body water (TBW) and surface area are estimated from anthropometry using equations developed several decades previously. Whether such equations remain valid in contemporary populations is not known.Methods: Total body water was measured using deuterium dilution in 672 subjects (265 infants aged < 1 year; 407 children and adolescents aged 1-19 years) during the period 1990-2003. TBW was predicted (a) using published equations, and (b) directly from data on age, sex, weight, and height.Results: Previously published equations, based on data obtained before 1970, significantly overestimated TBW, with average biases ranging from 4% to 11%. For all equations, the overestimation of TBW was greatest in infancy. New equations were generated. The best equation, incorporating log weight, log height, age, and sex, had a standard error of the estimate of 7.8%.Conclusions: Secular trends in the nutritional status of infants and children are altering the relation between age or weight and TBW. Equations developed in previous decades significantly overestimate TBW in all age groups, especially infancy; however, the relation between TBW and weight may continue to change. This scenario is predicted to apply more generally to many aspects of paediatric clinical practice in which dosages are calculated on the basis of anthropometric data collected in previous decades. date: 2005-09 publisher: B M J PUBLISHING GROUP official_url: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC1720559/?tool=pubmed oa_status: green pmcid: PMC1720559 primo: open primo_central: open_green article_type_text: Article verified: verified_batch elements_source: Web of Science elements_id: 69253 doi: 10.1136/adc.2004.067538 lyricists_name: Cole, Timothy lyricists_name: Fewtrell, Mary lyricists_name: Wells, Jonathan lyricists_name: Williams, Jane lyricists_id: TCOLE39 lyricists_id: MFEWT52 lyricists_id: JWELL04 lyricists_id: JWILL17 full_text_status: public publication: ARCH DIS CHILD volume: 90 number: 9 pagerange: 965 - 971 refereed: TRUE issn: 0003-9888 citation: Wells, JCK; Fewtrell, MS; Davies, PSW; Williams, JE; Coward, WA; Cole, TJ; (2005) Prediction of total body water in infants and children. ARCH DIS CHILD , 90 (9) 965 - 971. 10.1136/adc.2004.067538 <https://doi.org/10.1136/adc.2004.067538>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/15090/1/15090.pdf