%X T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte-TEC cross-talk in the embryonic mouse thymus during the last week of gestation. %L discovery1508779 %J Journal of Developmental Biology %A A Barbarulo %A C-I Lau %A K Mengrelis %A S Ross %A A Solanki %A JI Saldaña %A T Crompton %O Copyright © 2016 by the Authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). %V 4 %C Switzerland %D 2016 %K thymus; Hedgehog; Shh; Ihh; T cell development; thymic epithelial cell (TEC); Gli3; Gli2; Gli1 %N 3 %T Hedgehog Signalling in the Embryonic Mouse Thymus